2e2c
From Proteopedia
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{{STRUCTURE_2e2c| PDB=2e2c | SCENE= }} | {{STRUCTURE_2e2c| PDB=2e2c | SCENE= }} | ||
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===E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS=== | ===E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS=== | ||
| + | {{ABSTRACT_PUBMED_10350465}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. | |
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| - | -- | + | |
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| - | == | + | ==See Also== |
| - | [[ | + | *[[Ubiquitin conjugating enzyme|Ubiquitin conjugating enzyme]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:010350465</ref><references group="xtra"/> | + | <ref group="xtra">PMID:010350465</ref><references group="xtra"/><references/> |
[[Category: Spisula solidissima]] | [[Category: Spisula solidissima]] | ||
[[Category: Ubiquitin--protein ligase]] | [[Category: Ubiquitin--protein ligase]] | ||
Revision as of 08:30, 23 April 2014
Contents |
E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS
Template:ABSTRACT PUBMED 10350465
Function
[UBE2C_SPISO] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).
About this Structure
2e2c is a 1 chain structure with sequence from Spisula solidissima. This structure supersedes the now removed PDB entries and 1e2c. Full crystallographic information is available from OCA.
See Also
Reference
- Jiang F, Basavappa R. Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution. Biochemistry. 1999 May 18;38(20):6471-8. PMID:10350465 doi:10.1021/bi9901329
