2bf7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2bf7" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2bf7.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_2bf7", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_2bf7| PDB=2bf7 | SCENE= }}
{{STRUCTURE_2bf7| PDB=2bf7 | SCENE= }}
- 
===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND BIOPTERIN===
===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND BIOPTERIN===
 +
{{ABSTRACT_PUBMED_16055151}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/PTR1_LEIMA PTR1_LEIMA]] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).<ref>PMID:7972081</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16055151}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 16055151 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_16055151}}
+
==About this Structure==
==About this Structure==
[[2bf7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BF7 OCA].
[[2bf7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BF7 OCA].
 +
 +
==See Also==
 +
*[[Pteridine reductase|Pteridine reductase]]
==Reference==
==Reference==
-
<ref group="xtra">PMID:016055151</ref><references group="xtra"/>
+
<ref group="xtra">PMID:016055151</ref><references group="xtra"/><references/>
[[Category: Leishmania major]]
[[Category: Leishmania major]]
[[Category: Pteridine reductase]]
[[Category: Pteridine reductase]]

Revision as of 08:35, 23 April 2014

Template:STRUCTURE 2bf7

Contents

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND BIOPTERIN

Template:ABSTRACT PUBMED 16055151

Function

[PTR1_LEIMA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).[1]

About this Structure

2bf7 is a 4 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA.

See Also

Reference

  • Schuttelkopf AW, Hardy LW, Beverley SM, Hunter WN. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. J Mol Biol. 2005 Sep 9;352(1):105-16. PMID:16055151 doi:http://dx.doi.org/10.1016/j.jmb.2005.06.076
  1. ↑ Bello AR, Nare B, Freedman D, Hardy L, Beverley SM. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11442-6. PMID:7972081

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bf7"
Personal tools