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2c91
From Proteopedia
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{{STRUCTURE_2c91| PDB=2c91 | SCENE= }} | {{STRUCTURE_2c91| PDB=2c91 | SCENE= }} | ||
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===MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5=== | ===MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5=== | ||
| + | {{ABSTRACT_PUBMED_16460003}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ARK72_MOUSE ARK72_MOUSE]] Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).<ref>PMID:16460003</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016460003</ref>< | + | <ref group="xtra">PMID:016460003</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Ellis, E M.]] | [[Category: Ellis, E M.]] | ||
Revision as of 08:40, 23 April 2014
Contents |
MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5
Template:ABSTRACT PUBMED 16460003
Function
[ARK72_MOUSE] Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).[1]
About this Structure
2c91 is a 10 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k
- ↑ Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k
