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4nag
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Xanthomonins I III are a New Class of Lasso Peptides Featuringa Seven-Membered Macrolactam Ring== |
| + | <StructureSection load='4nag' size='340' side='right' caption='[[4nag]], [[Resolution|resolution]] 0.81Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | [[4nag]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAG OCA]. <br> | ||
| + | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Lasso peptides belong to the class of ribosomally synthesized and post-translationally modified peptides. Their common distinguishing feature is an N-terminal macrolactam ring that is threaded by the C-terminal tail. This lasso fold is maintained through steric interactions. The isolation and characterization of xanthomonins I-III, the first lasso peptides featuring macrolactam rings consisting of only seven amino acids, is now presented. The crystal structure of xanthomonin I and the NMR structure of xanthomonin II were also determined. A total of 25 variants of xanthomonin II were generated to probe different aspects of the biosynthesis, stability, and fold maintenance. These mutational studies reveal the limits such a small ring imposes on the threading and show that every plug amino acid larger than serine is able to maintain a heat-stable lasso fold in the xanthomonin II scaffold. | ||
| - | + | Xanthomonins I-III: A New Class of Lasso Peptides with a Seven-Residue Macrolactam Ring.,Hegemann JD, Zimmermann M, Zhu S, Steuber H, Harms K, Xie X, Marahiel MA Angew Chem Int Ed Engl. 2014 Jan 20. doi: 10.1002/anie.201309267. PMID:24446383<ref>PMID:24446383</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Harms, K.]] | ||
| + | [[Category: Hegemann, J D.]] | ||
| + | [[Category: Marahiel, M A.]] | ||
| + | [[Category: Steuber, H.]] | ||
| + | [[Category: Xie, X.]] | ||
| + | [[Category: Zhu, S.]] | ||
| + | [[Category: Zimmermann, M.]] | ||
| + | [[Category: Biosynthesis]] | ||
| + | [[Category: Biosynthetic protein]] | ||
| + | [[Category: Lariat knot]] | ||
| + | [[Category: Lasso fold]] | ||
| + | [[Category: Lasso peptide]] | ||
| + | [[Category: Macrocycle]] | ||
| + | [[Category: Natural product]] | ||
| + | [[Category: Steric hindrance]] | ||
Revision as of 07:44, 30 April 2014
Xanthomonins I III are a New Class of Lasso Peptides Featuringa Seven-Membered Macrolactam Ring
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