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4bws
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.== |
| - | + | <StructureSection load='4bws' size='340' side='right' caption='[[4bws]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | [[4bws]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWS OCA]. <br> | |
| - | + | <b>Related:</b> [[4bwq|4bwq]]<br> | |
| - | + | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | |
| - | + | == Disease == | |
| + | [[http://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN]] X-linked intellectual deficit, Sutherland-Haan type;X-linked intellectual deficit, Golabi-Ito-Hall type;X-linked intellectual deficit, Porteous type;Hamel cerebro-palato-cardiac syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN]] Essential role in pre-mRNA splicing. [[http://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN]] May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.<ref>PMID:10332029</ref> <ref>PMID:10198427</ref> <ref>PMID:12062018</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kojima, R.]] | ||
| + | [[Category: Mizuguchi, M.]] | ||
| + | [[Category: Morimoto, T.]] | ||
| + | [[Category: Nabeshima, Y.]] | ||
| + | [[Category: Obita, T.]] | ||
| + | [[Category: Okazawa, H.]] | ||
| + | [[Category: Serita, T.]] | ||
| + | [[Category: Neurodegenerative disorder]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:56, 30 April 2014
Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.
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