|
|
| Line 9: |
Line 9: |
| | * Field of Expertise or Study: Pharmacy | | * Field of Expertise or Study: Pharmacy |
| | | | |
| - | *[[User:Jaakko Itkonen/Sandbox CNTF]] | + | *[[User:Jaakko Itkonen]] |
| - | | + | |
| - | ==Introduction==
| + | |
| - | | + | |
| - | Ciliary neutrophic factor (CNTF) is a nerve growth factor belonging to the interleukin-6 family
| + | |
| - | of neuropoietic cytokines.
| + | |
| - | Other members of this family include leukaemie inhibitory factor (LIF), IL-6, IL-11 and
| + | |
| - | oncostatin M (Wang 2012).
| + | |
| - | | + | |
| - | | + | |
| - | | + | |
| - | <scene name='58/584309/Cntf/1'>TextToBeDisplayed</scene>
| + | |
| - | | + | |
| - | Fig. 1 X-ray structure of a truncated form of hCNTF (2-187)
| + | |
| - | | + | |
| - | ==Structure==
| + | |
| - | Overview
| + | |
| - | | + | |
| - | CNTF is a roughly 22.7 kDa protein consisting of a single
| + | |
| - | polypeptide chain of 200 amino acid residues.
| + | |
| - | Like with many other cytokines, the tertiary structure of CNTF
| + | |
| - | consists of four anti-parallel α-helices (A-D), where helices A-B and C-D are connected
| + | |
| - | by two cross-over loops and helices B-C by one short loop.
| + | |
| - | | + | |
| - | | + | |
| - | ==Disease==
| + | |
| - | | + | |
| - | ==References==
| + | |
| - | | + | |
| - | Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GCA, Gascan H and Gauchat J-F: Expression of biologically active mouse ciliary neurotrophic factor (CNTF) and soluble CNTFRα in Eschericia coli and characterization of their functional specificities. Eur Cytokine Netw 15: 255-262 (2004).
| + | |
| - | | + | |
| - | Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM and Wen R: CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS One 5: 1-7 (2010).
| + | |
| - | | + | |
| - | Li Y, Wen R, Banzon T, Maminishkis A and Miller SS: CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One 6: 1-7 (2011).
| + | |
| - | | + | |
| - | McDonald NQ, Panayotatos N and Hendrickson WA: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J 14: 2689-2699 (1995).
| + | |
| - | | + | |
| - | Richardson PM: Ciliary neurotrophic factor: A review. Pharmac Ther 63: 187-198 (1994).
| + | |
| - | | + | |
| - | Sieving PA, Caruse RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR and Bush RA: Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. PNAS 103: 3896-3901 (2006).
| + | |
| - | | + | |
| - | Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD and Wiegand SJ: The ciliary neurotrophic factor and its receptor, CNTFRα. Pharm Acta Helv 74: 265-272 (2000).
| + | |
| - | | + | |
| - | Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM and Sieving PA: Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 26: 13523-13530 (2006).
| + | |
| - | | + | |
| - | Wen R, Tao W, Li Y and Sieving PA: CNTF and retina. Prog Retin Eye Res 31: 136-151 (2012).
| + | |
