2y6s

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[[Image:2y6s.png|left|200px]]
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==Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope==
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<StructureSection load='2y6s' size='340' side='right' caption='[[2y6s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2y6s]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6S OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6s RCSB], [http://www.ebi.ac.uk/pdbsum/2y6s PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Antibody 14G7 is protective against lethal Ebola virus challenge, and recognizes a distinct linear epitope in the prominent mucin-like domain of the Ebola virus glycoprotein GP. The structure of 14G7 in complex with its linear peptide epitope has now been determined to 2.8 A. The structure shows that this GP sequence forms a tandem ss hairpin structure that binds deeply into a cleft in the antibody-combining site. A key threonine at the apex of one turn is critical for antibody interaction and is conserved among all ebolaviruses. This work provides further insight into the mechanism of protection by antibodies that target the protruding, highly accessible mucin-like domain of Ebola virus and the structural framework for understanding and characterizing candidate immunotherapeutics.
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Structure of an Ebola virus-protective antibody in complex with its mucin-domain linear epitope.,Olal D, Kuehne A, Bale S, Halfmann P, Hashiguchi T, Fusco ML, Lee JE, King LB, Kawaoka Y, Dye JM Jr, Saphire EO J Virol. 2011 Dec 14. PMID:22171276<ref>PMID:22171276</ref>
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The line below this paragraph, containing "STRUCTURE_2y6s", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2y6s| PDB=2y6s | SCENE= }}
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===Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22171276}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22171276 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22171276}}
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==About this Structure==
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[[2y6s]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6S OCA].
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==Reference==
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<ref group="xtra">PMID:022171276</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Bale, S.]]
[[Category: Bale, S.]]

Revision as of 07:49, 14 May 2014

Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope

2y6s, resolution 2.80Å

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