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3b0s

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[[Image:3b0s.jpg|left|200px]]
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==Crystal Structure of (Gly-Pro-Hyp)9==
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<StructureSection load='3b0s' size='340' side='right' caption='[[3b0s]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b0s]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v7h|1v7h]], [[1v4f|1v4f]], [[3ah9|3ah9]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b0s RCSB], [http://www.ebi.ac.uk/pdbsum/3b0s PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Collagens have long been believed to adopt a triple-stranded molecular structure with a 10/3 symmetry (ten triplet units in three turns) and an axial repeat of 29 A. This belief even persisted after an alternative structure with a 7/2 symmetry (seven triplet units in two turns) with an axial repeat of 20 A had been proposed. The uncertainty regarding the helical symmetry of collagens is attributed to inadequate X-ray fiber diffraction data. Therefore, for better understanding of the collagen helix, single-crystal analyses of peptides with simplified characteristic amino acid sequences and similar compositions to collagens have long been awaited. Here we report the crystal structure of (Gly-Pro-Hyp)(9) peptide at a resolution of 1.45 A. The repeating unit of this peptide, Gly-Pro-Hyp, is the most typical sequence present in collagens, and it has been used as a basic repeating unit in fiber diffraction analyses of collagen. The (Gly-Pro-Hyp)(9) peptide adopts a triple-stranded structure with an average helical symmetry close to the ideal 7/2 helical model for collagen. This observation strongly suggests that the average molecular structure of collagen is not the accepted Rich and Crick 10/3 helical model but is a 7/2 helical conformation. (c) 2012 Wiley Periodicals, Inc. Biopolymers 97: 607-616, 2012.
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Crystal structure of (Gly-Pro-Hyp)(9) : Implications for the collagen molecular model.,Okuyama K, Miyama K, Mizuno K, Bachinger HP Biopolymers. 2012 Aug;97(8):607-16. doi: 10.1002/bip.22048. PMID:22605552<ref>PMID:22605552</ref>
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The line below this paragraph, containing "STRUCTURE_3b0s", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3b0s| PDB=3b0s | SCENE= }}
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===Crystal Structure of (Gly-Pro-Hyp)9===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22605552}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22605552 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22605552}}
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==About this Structure==
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[[3b0s]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0S OCA].
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==Reference==
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<ref group="xtra">PMID:022605552</ref><references group="xtra"/>
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[[Category: Bachinger, H P.]]
[[Category: Bachinger, H P.]]
[[Category: Miyama, K.]]
[[Category: Miyama, K.]]

Revision as of 11:06, 14 May 2014

Crystal Structure of (Gly-Pro-Hyp)9

3b0s, resolution 1.45Å

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