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3b1f

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[[Image:3b1f.png|left|200px]]
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==Crystal structure of prephenate dehydrogenase from Streptococcus mutans==
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<StructureSection load='3b1f' size='340' side='right' caption='[[3b1f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B1F FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMU_781 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1309 Streptococcus mutans])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prephenate_dehydrogenase Prephenate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.12 1.3.1.12] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b1f RCSB], [http://www.ebi.ac.uk/pdbsum/3b1f PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Prephenate dehydrogenase (PDH) is a bacterial enzyme that catalyzes conversion of prephenate to 4-hydroxyphenylpyruvate through the oxidative decarboxylation pathway for tyrosine biosynthesis. This enzymatic pathway exists in prokaryotes but is absent in mammals, indicating that it is a potential target for the development of new antibiotics. The crystal structure of PDH from Streptococcus mutans in a complex with NAD(+) shows that the enzyme exists as a homo-dimer, each monomer consisting of two domains, a modified nucleotide binding N-terminal domain and a helical prephenate C-terminal binding domain. The latter is the dimerization domain. A structural comparison of PDHs from mesophilic S. mutans and thermophilic Aquifex aeolicus showed differences in the long loop between beta6 and beta7, which may be a reason for the high K(m) values of PDH from Streptococcus mutans.
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<!--
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Crystal structure of prephenate dehydrogenase from Streptococcus mutans.,Ku HK, Do NH, Song JS, Choi S, Yeon SH, Shin MH, Kim KJ, Park SR, Park IY, Kim SK, Lee SJ Int J Biol Macromol. 2011 Nov 1;49(4):761-6. Epub 2011 Jul 20. PMID:21798280<ref>PMID:21798280</ref>
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The line below this paragraph, containing "STRUCTURE_3b1f", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3b1f| PDB=3b1f | SCENE= }}
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===Crystal structure of prephenate dehydrogenase from Streptococcus mutans===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21798280}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21798280 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21798280}}
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==About this Structure==
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[[3b1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1F OCA].
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==Reference==
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<ref group="xtra">PMID:021798280</ref><references group="xtra"/>
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[[Category: Prephenate dehydrogenase]]
[[Category: Prephenate dehydrogenase]]
[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]

Revision as of 11:07, 14 May 2014

Crystal structure of prephenate dehydrogenase from Streptococcus mutans

3b1f, resolution 2.10Å

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