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1a8b
From Proteopedia
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| - | [[Image:1a8b.gif|left|200px]] | + | [[Image:1a8b.gif|left|200px]] |
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| - | '''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE''' | + | {{Structure |
| + | |PDB= 1a8b |SIZE=350|CAPTION= <scene name='initialview01'>1a8b</scene>, resolution 1.9Å | ||
| + | |SITE= <scene name='pdbsite=GPE:Gpe+Binding+Site+(Includes+1+Ca+Ion)'>GPE</scene> | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=GPE:L-ALPHA-GLYCEROPHOSPHORYLETHANOLAMINE'>GPE</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1A8B is a [ | + | 1A8B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8B OCA]. |
==Reference== | ==Reference== | ||
| - | Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:[http:// | + | Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583670 7583670] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: phospholipid analog]] | [[Category: phospholipid analog]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:54:20 2008'' |
Revision as of 07:54, 20 March 2008
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| , resolution 1.9Å | |||||||
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| Sites: | |||||||
| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE
Overview
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
About this Structure
1A8B is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670
Page seeded by OCA on Thu Mar 20 09:54:20 2008
