1agi
From Proteopedia
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| - | [[Image:1agi.gif|left|200px]] | + | [[Image:1agi.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF BOVINE ANGIOGENIN AT 1.5 ANGSTROMS RESOLUTION''' | + | {{Structure |
| + | |PDB= 1agi |SIZE=350|CAPTION= <scene name='initialview01'>1agi</scene>, resolution 1.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''CRYSTAL STRUCTURE OF BOVINE ANGIOGENIN AT 1.5 ANGSTROMS RESOLUTION''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AGI is a [ | + | 1AGI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGI OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of bovine angiogenin at 1.5-A resolution., Acharya KR, Shapiro R, Riordan JF, Vallee BL, Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2949-53. PMID:[http:// | + | Crystal structure of bovine angiogenin at 1.5-A resolution., Acharya KR, Shapiro R, Riordan JF, Vallee BL, Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2949-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7708754 7708754] |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: endonuclease]] | [[Category: endonuclease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:57:15 2008'' |
Revision as of 07:57, 20 March 2008
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| , resolution 1.5Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF BOVINE ANGIOGENIN AT 1.5 ANGSTROMS RESOLUTION
Overview
The capacity of angiogenin (Ang) to induce blood vessel growth is critically dependent on its ribonucleolytic activity. Crystallography and mutagenesis of human Ang have previously shown that its pyrimidine binding site is obstructed by Gln-117, implying that a conformational change is a key part of the mechanism of Ang action. The 1.5-A-resolution crystal structure of bovine Ang, in which glutamic acid is substituted for Gln-117, now confirms that a blocked active site is characteristic of these proteins. Indeed, the inactive conformation of bovine Ang is stabilized by a more extensive set of interactions than is that of human Ang. The three-dimensional structure of the putative receptor binding site is also well conserved in the two proteins. The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.
About this Structure
1AGI is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Crystal structure of bovine angiogenin at 1.5-A resolution., Acharya KR, Shapiro R, Riordan JF, Vallee BL, Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2949-53. PMID:7708754
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