1ais
From Proteopedia
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| - | [[Image:1ais.jpg|left|200px]] | + | [[Image:1ais.jpg|left|200px]] |
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| - | '''TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI''' | + | {{Structure |
| + | |PDB= 1ais |SIZE=350|CAPTION= <scene name='initialview01'>1ais</scene>, resolution 2.100Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AIS is a [ | + | 1AIS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_woesei Pyrococcus woesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AIS OCA]. |
==Reference== | ==Reference== | ||
| - | The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box., Kosa PF, Ghosh G, DeDecker BS, Sigler PB, Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6042-7. PMID:[http:// | + | The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box., Kosa PF, Ghosh G, DeDecker BS, Sigler PB, Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6042-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9177165 9177165] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Pyrococcus woesei]] | [[Category: Pyrococcus woesei]] | ||
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[[Category: transcription]] | [[Category: transcription]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:58:09 2008'' |
Revision as of 07:58, 20 March 2008
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TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI
Overview
Archaea possess a basal transcriptional apparatus that resembles that of eukaryotes. Here we report the 2.1-A crystal structure of the archaeal transcription factor complex formed by the TATA-box-binding protein (TBP), the transcription factor IIB homolog, and a DNA target, all from the hyperthermophile Pyrococcus woesei. The overall fold of these two basal transcription factors is essentially the same as that of their eukaryotic counterparts. However, in comparison with the eukaryotic complexes, the archaeal TBP-DNA interface is more symmetrical, and in this structure the orientation of the preinitiation complex assembly on the promoter is inverted with respect to that seen in all crystal structures of comparable eukaryotic systems. This study of the structural details of an archaeal transcription factor complex presents the opportunity to examine the evolution of the basal eukaryotic transcriptional apparatus from a stereochemical viewpoint and to extend our understanding of the physical biochemistry of transcriptional initiation.
About this Structure
1AIS is a Protein complex structure of sequences from Pyrococcus woesei. Full crystallographic information is available from OCA.
Reference
The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box., Kosa PF, Ghosh G, DeDecker BS, Sigler PB, Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6042-7. PMID:9177165
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