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1aq1
From Proteopedia
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| - | [[Image:1aq1.gif|left|200px]] | + | [[Image:1aq1.gif|left|200px]] |
| - | + | ||
| - | '''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE''' | + | {{Structure |
| + | |PDB= 1aq1 |SIZE=350|CAPTION= <scene name='initialview01'>1aq1</scene>, resolution 2.0Å | ||
| + | |SITE= <scene name='pdbsite=STB:Staurosporine+Binding+Site'>STB</scene> | ||
| + | |LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AQ1 is a [ | + | 1AQ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQ1 OCA]. |
==Reference== | ==Reference== | ||
| - | Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:[http:// | + | Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334743 9334743] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: staurosporine]] | [[Category: staurosporine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:00:55 2008'' |
Revision as of 08:00, 20 March 2008
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| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | |||||||
| Activity: | Transferred entry: 2.7.11.1, with EC number 2.7.1.37 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Overview
Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.
About this Structure
1AQ1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743
Page seeded by OCA on Thu Mar 20 10:00:55 2008
