3qr0

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[[Image:3qr0.png|left|200px]]
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==Crystal Structure of S. officinalis PLC21==
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<StructureSection load='3qr0' size='340' side='right' caption='[[3qr0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sepia_officinalis Sepia officinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QR0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qr1|3qr1]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qr0 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr0 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The enzyme phospholipase C-beta (PLCbeta) is a crucial regulator of intracellular calcium levels whose activity is controlled by heptahelical receptors that couple to members of the G(q) family of heterotrimeric G proteins. We have determined atomic structures of two invertebrate homologs of PLCbeta (PLC21) from cephalopod retina and identified a helix from the C-terminal regulatory region that interacts with a conserved surface of the catalytic core of the enzyme. Mutations designed to disrupt the analogous interaction in human PLCbeta3 considerably increase basal activity and diminish stimulation by Galpha(q). Galpha(q) binding requires displacement of the autoinhibitory helix from the catalytic core, thus providing an allosteric mechanism for activation of PLCbeta.
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An autoinhibitory helix in the C-terminal region of phospholipase C-beta mediates Galpha(q) activation.,Lyon AM, Tesmer VM, Dhamsania VD, Thal DM, Gutierrez J, Chowdhury S, Suddala KC, Northup JK, Tesmer JJ Nat Struct Mol Biol. 2011 Aug 7;18(9):999-1005. doi: 10.1038/nsmb.2095. PMID:21822282<ref>PMID:21822282</ref>
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The line below this paragraph, containing "STRUCTURE_3qr0", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_3qr0| PDB=3qr0 | SCENE= }}
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===Crystal Structure of S. officinalis PLC21===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21822282}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21822282 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21822282}}
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==About this Structure==
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[[3qr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sepia_officinalis Sepia officinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR0 OCA].
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==Reference==
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<ref group="xtra">PMID:021822282</ref><references group="xtra"/>
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[[Category: Sepia officinalis]]
[[Category: Sepia officinalis]]
[[Category: Lyon, A M.]]
[[Category: Lyon, A M.]]

Revision as of 05:21, 4 June 2014

Crystal Structure of S. officinalis PLC21

3qr0, resolution 2.00Å

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