1awi

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[[Image:1awi.gif|left|200px]]<br /><applet load="1awi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1awi.gif|left|200px]]
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caption="1awi, resolution 2.2&Aring;" />
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'''HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE'''<br />
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{{Structure
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|PDB= 1awi |SIZE=350|CAPTION= <scene name='initialview01'>1awi</scene>, resolution 2.2&Aring;
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|SITE= <scene name='pdbsite=PPA:Poly-L-PRO+Binding+Site'>PPA</scene> and <scene name='pdbsite=PPB:Poly-L-PRO+Binding+Site'>PPB</scene>
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1AWI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Known structural/functional Sites: <scene name='pdbsite=PPA:Poly-L-PRO+Binding+Site'>PPA</scene> and <scene name='pdbsite=PPB:Poly-L-PRO+Binding+Site'>PPB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWI OCA].
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1AWI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWI OCA].
==Reference==
==Reference==
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Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation., Mahoney NM, Janmey PA, Almo SC, Nat Struct Biol. 1997 Nov;4(11):953-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9360613 9360613]
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Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation., Mahoney NM, Janmey PA, Almo SC, Nat Struct Biol. 1997 Nov;4(11):953-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9360613 9360613]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: profilin]]
[[Category: profilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:03:10 2008''

Revision as of 08:03, 20 March 2008

Image:1awi.gif


PDB ID 1awi

Drag the structure with the mouse to rotate
, resolution 2.2Å
Sites: and
Coordinates: save as pdb, mmCIF, xml



HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE


Overview

Profilin, a ubiquitous low molecular weight (13,000-15,000 M(r)) actin binding protein, regulates the formation of F-actin structures in vivo, and is localized to specific cellular regions through interaction with proline-rich sequences. Here we report the 2.2 A X-ray structure of the complex between human platelet profilin (HPP) and a decamer of L-proline (L-Pro10). The L-Pro10 peptide adopts a left-handed type II poly-L-proline helix (PPII) and binds to a highly conserved patch of aromatic amino acids on the surface of profilin. The peptide and actin binding sites reside on orthogonal surfaces, and L-Pro10 binding does not result in a conformational rearrangement of HPP. This structure suggests a mechanism for the localization of profilin and its actin-related activities to sites of actin filament assembly in vivo.

About this Structure

1AWI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation., Mahoney NM, Janmey PA, Almo SC, Nat Struct Biol. 1997 Nov;4(11):953-60. PMID:9360613

Page seeded by OCA on Thu Mar 20 10:03:10 2008

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