3t7s

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[[Image:3t7s.png|left|200px]]
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==Crystal structure of complex of SAM and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482==
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<StructureSection load='3t7s' size='340' side='right' caption='[[3t7s]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3t7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_vulgatus Bacteroides vulgatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T7S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t7r|3t7r]], [[3t7t|3t7t]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BVU_3255 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=821 Bacteroides vulgatus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t7s RCSB], [http://www.ebi.ac.uk/pdbsum/3t7s PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Methylation is important for various cellular activities. To date, there is no report of any methyltransferase structure from the human intestine antibiotic resistant pathogen Bacteroides vulgatus. The protein BVU_3255 from B. vulgatus ATCC 8482 belongs to a SAM-dependent methyltransferase. Here, we report the crystal structure of apo BVU_3255, and its complexes with SAM and SAH, which revealed a typical class I Rossmann Fold Methyltransferase. Isothermal titration calorimetric studies showed that both SAM and SAH bind with equal affinity. The structural and sequence analysis suggested that BVU_3255 is a small molecule methyltransferase and involved in methylating the intermediates in ubiquinone biosynthesis pathway.
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Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus.,Kumar V, Sivaraman J J Struct Biol. 2011 Aug 22. PMID:21872662<ref>PMID:21872662</ref>
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The line below this paragraph, containing "STRUCTURE_3t7s", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_3t7s| PDB=3t7s | SCENE= }}
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===Crystal structure of complex of SAM and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21872662}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21872662 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21872662}}
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==About this Structure==
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[[3t7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_vulgatus Bacteroides vulgatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7S OCA].
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==Reference==
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<ref group="xtra">PMID:021872662</ref><references group="xtra"/>
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[[Category: Bacteroides vulgatus]]
[[Category: Bacteroides vulgatus]]
[[Category: Kumar, V.]]
[[Category: Kumar, V.]]

Revision as of 06:27, 5 June 2014

Crystal structure of complex of SAM and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482

3t7s, resolution 2.20Å

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