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3zy7

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[[Image:3zy7.png|left|200px]]
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==Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer==
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<StructureSection load='3zy7' size='340' side='right' caption='[[3zy7]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zy7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZY7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a7b|2a7b]], [[1gyu|1gyu]], [[1gyw|1gyw]], [[1w63|1w63]], [[1gyv|1gyv]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zy7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zy7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zy7 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Computational design of novel protein-protein interfaces is a test of our understanding of protein interactions and has the potential to allow modification of cellular physiology. Methods for designing high-affinity interactions that adopt a predetermined binding mode have proved elusive, suggesting the need for new strategies that simplify the design process. A solvent-exposed backbone on a beta-strand is thought of as "sticky" and beta-strand pairing stabilizes many naturally occurring protein complexes. Here, we computationally redesign a monomeric protein to form a symmetric homodimer by pairing exposed beta-strands to form an intermolecular beta-sheet. A crystal structure of the designed complex closely matches the computational model (rmsd = 1.0 A). This work demonstrates that beta-strand pairing can be used to computationally design new interactions with high accuracy.
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Computational design of a symmetric homodimer using beta-strand assembly.,Stranges PB, Machius M, Miley MJ, Tripathy A, Kuhlman B Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20562-7. Epub 2011 Dec 5. PMID:22143762<ref>PMID:22143762</ref>
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The line below this paragraph, containing "STRUCTURE_3zy7", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_3zy7| PDB=3zy7 | SCENE= }}
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===Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Adaptin|Adaptin]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22143762}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22143762 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22143762}}
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</StructureSection>
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==About this Structure==
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[[3zy7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZY7 OCA].
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==Reference==
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<ref group="xtra">PMID:022143762</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Kuhlman, B.]]
[[Category: Kuhlman, B.]]

Revision as of 07:39, 5 June 2014

Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer

3zy7, resolution 1.09Å

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