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1ce4

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[[Image:1ce4.png|left|200px]]
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==CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1==
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<StructureSection load='1ce4' size='340' side='right' caption='[[1ce4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ce4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CE4 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ce4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ce4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ce4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ce4 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The disulfide bridge closed cyclic peptide corresponding to the whole Consensus V3 loop of the envelope protein gp120 of HIV-1 was examined by proton 2D-NMR spectroscopy in water and in a 20% trifluoroethanol/water solution. In water, NOE data support a beta-turn conformation for the central conservative GPGR region and point towards partial formation of a helix in the C-terminal part. Upon addition of trifluoroethanol, a C-terminal helix is formed. This is evidenced by NOE data, alpha-proton chemical shift changes and changes in the JN alpha vicinal coupling constants. The C-terminal helix is amphipathic and also occurs in other examined strains. It could therefore be an important feature for the functioning of the V3 loop.
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{{STRUCTURE_1ce4| PDB=1ce4 | SCENE= }}
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The complete Consensus V3 loop peptide of the envelope protein gp120 of HIV-1 shows pronounced helical character in solution.,Vranken WF, Budesinsky M, Fant F, Boulez K, Borremans FA FEBS Lett. 1995 Oct 23;374(1):117-21. PMID:7589496<ref>PMID:7589496</ref>
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===CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_7589496}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1ce4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CE4 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:007589496</ref><ref group="xtra">PMID:015103622</ref><references group="xtra"/>
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[[Category: Borremans, F A.M.]]
[[Category: Borremans, F A.M.]]
[[Category: Budesinsky, M.]]
[[Category: Budesinsky, M.]]

Revision as of 05:43, 8 June 2014

CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1

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