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1bj8

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[[Image:1bj8.gif|left|200px]]<br /><applet load="1bj8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1bj8.gif|left|200px]]
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caption="1bj8" />
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'''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE'''<br />
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{{Structure
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|PDB= 1bj8 |SIZE=350|CAPTION= <scene name='initialview01'>1bj8</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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'''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1BJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA].
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1BJ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA].
==Reference==
==Reference==
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The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10210178 10210178]
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The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10210178 10210178]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: glycoprotein]]
[[Category: glycoprotein]]
[[Category: receptor]]
[[Category: receptor]]
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[[Category: signal transducer of il-6 type cytokines]]
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[[Category: signal transducer of il-6 type cytokine]]
[[Category: third n-terminal domain]]
[[Category: third n-terminal domain]]
[[Category: transmembrane]]
[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:11:47 2008''

Revision as of 08:11, 20 March 2008

Image:1bj8.gif


PDB ID 1bj8

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Coordinates: save as pdb, mmCIF, xml



THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE


Overview

The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.

About this Structure

1BJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:10210178

Page seeded by OCA on Thu Mar 20 10:11:47 2008

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