This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2fqn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2fqn" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2fqn.png|left|200px]]
+
==Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site==
 +
<StructureSection load='2fqn' size='340' side='right' caption='[[2fqn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2fqn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FQN FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fqn RCSB], [http://www.ebi.ac.uk/pdbsum/2fqn PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.
-
{{STRUCTURE_2fqn| PDB=2fqn | SCENE= }}
+
Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.,Kondo J, Urzhumtsev A, Westhof E Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:16452297<ref>PMID:16452297</ref>
-
===Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_16452297}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2fqn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQN OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:016452297</ref><references group="xtra"/>
+
[[Category: Kondo, J.]]
[[Category: Kondo, J.]]
[[Category: Urzhumtsev, A.]]
[[Category: Urzhumtsev, A.]]

Revision as of 07:03, 9 June 2014

Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site

2fqn, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fqn"
Views
Personal tools
Navigation
Toolbox