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1bl3
From Proteopedia
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| - | [[Image:1bl3.gif|left|200px]] | + | [[Image:1bl3.gif|left|200px]] |
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| - | '''CATALYTIC DOMAIN OF HIV-1 INTEGRASE''' | + | {{Structure |
| + | |PDB= 1bl3 |SIZE=350|CAPTION= <scene name='initialview01'>1bl3</scene>, resolution 2.00Å | ||
| + | |SITE= <scene name='pdbsite=ACT:Active+Site.+Mg-Binding+Site'>ACT</scene> | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CATALYTIC DOMAIN OF HIV-1 INTEGRASE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BL3 is a [ | + | 1BL3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL3 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases., Maignan S, Guilloteau JP, Zhou-Liu Q, Clement-Mella C, Mikol V, J Mol Biol. 1998 Sep 18;282(2):359-68. PMID:[http:// | + | Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases., Maignan S, Guilloteau JP, Zhou-Liu Q, Clement-Mella C, Mikol V, J Mol Biol. 1998 Sep 18;282(2):359-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9735293 9735293] |
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Zhou-Liu, Q.]] | [[Category: Zhou-Liu, Q.]] | ||
[[Category: MG]] | [[Category: MG]] | ||
| - | [[Category: | + | [[Category: aid]] |
[[Category: dna binding (viral)]] | [[Category: dna binding (viral)]] | ||
[[Category: dna integration]] | [[Category: dna integration]] | ||
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[[Category: polyprotein]] | [[Category: polyprotein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:12:28 2008'' |
Revision as of 08:12, 20 March 2008
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| , resolution 2.00Å | |||||||
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| Sites: | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CATALYTIC DOMAIN OF HIV-1 INTEGRASE
Overview
Human immunodeficiency virus (HIV) integrase is the enzyme responsible for insertion of a DNA copy of the viral genome into host DNA, an essential step in the replication cycle of HIV. HIV-1 integrase comprises three functional and structural domains: an N-terminal zinc-binding domain, a catalytic core domain and a C-terminal DNA-binding domain. The catalytic core domain with the F185H mutation has been crystallized without sodium cacodylate in a new crystal form, free and complexed with the catalytic metal Mg2+. The structures have been determined and refined to about 2.2 A. Unlike the previously reported structures, the three active-site carboxylate residues (D,D-35-E motif) are well ordered and both aspartate residues delineate a proper metal-binding site. Comparison of the active binding site of this domain with that of other members from the polynucleotidyl transferases superfamily shows a high level of similarity, providing a confident template for the design of antiviral agents.
About this Structure
1BL3 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases., Maignan S, Guilloteau JP, Zhou-Liu Q, Clement-Mella C, Mikol V, J Mol Biol. 1998 Sep 18;282(2):359-68. PMID:9735293
Page seeded by OCA on Thu Mar 20 10:12:28 2008
