1bvs
From Proteopedia
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| - | [[Image:1bvs.gif|left|200px]] | + | [[Image:1bvs.gif|left|200px]] |
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| - | '''RUVA COMPLEXED TO A HOLLIDAY JUNCTION.''' | + | {{Structure |
| + | |PDB= 1bvs |SIZE=350|CAPTION= <scene name='initialview01'>1bvs</scene>, resolution 3.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''RUVA COMPLEXED TO A HOLLIDAY JUNCTION.''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BVS is a [ | + | 1BVS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVS OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of an octameric RuvA-Holliday junction complex., Roe SM, Barlow T, Brown T, Oram M, Keeley A, Tsaneva IR, Pearl LH, Mol Cell. 1998 Sep;2(3):361-72. PMID:[http:// | + | Crystal structure of an octameric RuvA-Holliday junction complex., Roe SM, Barlow T, Brown T, Oram M, Keeley A, Tsaneva IR, Pearl LH, Mol Cell. 1998 Sep;2(3):361-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9774974 9774974] |
[[Category: Mycobacterium leprae]] | [[Category: Mycobacterium leprae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: holliday junction resolvase component]] | [[Category: holliday junction resolvase component]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:16:27 2008'' |
Revision as of 08:16, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
RUVA COMPLEXED TO A HOLLIDAY JUNCTION.
Overview
Holliday junctions occur as intermediates in homologous recombination and DNA repair. In bacteria, resolution of Holliday junctions is accomplished by the RuvABC system, consisting of a junction-specific helicase complex RuvAB, which promotes branch migration, and a junction-specific endonuclease RuvC, which nicks two strands. The crystal structure of a complex between the RuvA protein of M. leprae and a synthetic four-way junction has now been determined. Rather than binding on the open surface of a RuvA tetramer as previously suggested, the DNA is sandwiched between two RuvA tetramers, which form a closed octameric shell, stabilized by a conserved tetramer-tetramer interface. Interactions between the DNA backbone and helix-hairpin-helix motifs from both tetramers suggest a mechanism for strand separation promoted by RuvA.
About this Structure
1BVS is a Single protein structure of sequence from Mycobacterium leprae. Full crystallographic information is available from OCA.
Reference
Crystal structure of an octameric RuvA-Holliday junction complex., Roe SM, Barlow T, Brown T, Oram M, Keeley A, Tsaneva IR, Pearl LH, Mol Cell. 1998 Sep;2(3):361-72. PMID:9774974
Page seeded by OCA on Thu Mar 20 10:16:27 2008
