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User:John S. de Banzie/Sandbox 2
From Proteopedia
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==Carboxypeptidase A== | ==Carboxypeptidase A== | ||
<StructureSection load='4cpa' size='400' side='right' caption='Carboxypeptidase A, [[4cpa]]' scene='59/590622/4cpaspacefill/4'> | <StructureSection load='4cpa' size='400' side='right' caption='Carboxypeptidase A, [[4cpa]]' scene='59/590622/4cpaspacefill/4'> | ||
| - | Carboxypeptidase A catalyses the release of the C-terminal amino acid from a polypeptide chain. The initial image shows carboxypeptidase with a | + | Carboxypeptidase A catalyses the release of the C-terminal amino acid from a polypeptide chain. The initial image shows carboxypeptidase with a tetrapeptide (green) bound in the active site. |
The enzyme has <scene name='59/590622/4cpacartoon/2'>mixed secondary structure</scene>. A <scene name='59/590622/4cpacartoonzn/3'>zinc ion</scene> is present. The ion is involved in binding and catalysis. | The enzyme has <scene name='59/590622/4cpacartoon/2'>mixed secondary structure</scene>. A <scene name='59/590622/4cpacartoonzn/3'>zinc ion</scene> is present. The ion is involved in binding and catalysis. | ||
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| + | Three interactions hold the substrate in the active site. | ||
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| + | 1. <scene name='59/590622/4cpabindone/1'>Between the carbonyl group of the penultimate residue in the substrate and the zinc ion and an arginine in the enzyme</scene>. | ||
| + | 2. <scene name='59/590622/4cpabindone/1'>Between the C-terminal carboxyl group and asparagine, arginine, and tyrosine residues in the enzyme</scene>. | ||
| + | 3. <scene name='59/590622/4cpabindone/1'>Between the C-terminal R group and a hydrophobic pocket in the enzyme</scene>. | ||
== Function == | == Function == | ||
Revision as of 21:39, 12 June 2014
Carboxypeptidase A
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