1c1e

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[[Image:1c1e.jpg|left|200px]]<br /><applet load="1c1e" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1c1e.jpg|left|200px]]
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caption="1c1e, resolution 1.9&Aring;" />
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'''CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN'''<br />
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{{Structure
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|PDB= 1c1e |SIZE=350|CAPTION= <scene name='initialview01'>1c1e</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ENH:1,7,8,9,10,10-HEXACHLORO-4-METHYL-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE'>ENH</scene> and <scene name='pdbligand=DMR:2-HYDROXY-SUCCINIC ACID'>DMR</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1C1E is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ENH:'>ENH</scene> and <scene name='pdbligand=DMR:'>DMR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].
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1C1E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].
==Reference==
==Reference==
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Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10600746 10600746]
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Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600746 10600746]
[[Category: Antibodies]]
[[Category: Antibodies]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: immunoglobulin]]
[[Category: immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:01:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:18:38 2008''

Revision as of 08:18, 20 March 2008

Image:1c1e.jpg


PDB ID 1c1e

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN


Overview

The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.

About this Structure

1C1E is a Protein complex structure of sequences from Mus musculus. The following page contains interesting information on the relation of 1C1E with [Antibodies]. Full crystallographic information is available from OCA.

Reference

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:10600746

Page seeded by OCA on Thu Mar 20 10:18:38 2008

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