1c5c
From Proteopedia
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| - | [[Image:1c5c.gif|left|200px]] | + | [[Image:1c5c.gif|left|200px]] |
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| - | '''DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX''' | + | {{Structure |
| + | |PDB= 1c5c |SIZE=350|CAPTION= <scene name='initialview01'>1c5c</scene>, resolution 1.61Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=TK4:2-ACETYLAMINO-NAPTHALENE-1,5-DISULFONIC+ACID'>TK4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1C5C is a [ | + | 1C5C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus_+_homo_sapiens Mus musculus + homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5C OCA]. |
==Reference== | ==Reference== | ||
| - | Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8., Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA, J Mol Biol. 2000 Oct 6;302(5):1213-25. PMID:[http:// | + | Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8., Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA, J Mol Biol. 2000 Oct 6;302(5):1213-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11183784 11183784] |
[[Category: Mus musculus + homo sapiens]] | [[Category: Mus musculus + homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:19:59 2008'' |
Revision as of 08:20, 20 March 2008
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| , resolution 1.61Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX
Overview
Antibody 21D8 catalyzes the solvent-sensitive decarboxylation of 3-carboxybenzisoxazoles. The crystal structure of chimeric Fab 21D8 with and without hapten at 1.61 A and 2.10 A, respectively, together with computational analysis, shows how a melange of polar and non-polar sites are exploited to achieve both substrate binding and acceleration of a reaction normally facilitated by purely aprotic dipolar media. The striking similarity of the decarboxylase and a series of unrelated esterase antibodies also highlights the chemical versatility of structurally conserved anion binding sites and the relatively subtle changes involved in fine-tuning the immunoglobulin pocket for recognition of different ligands and catalysis of different reactions.
About this Structure
1C5C is a Protein complex structure of sequences from Mus musculus + homo sapiens. Full crystallographic information is available from OCA.
Reference
Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8., Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA, J Mol Biol. 2000 Oct 6;302(5):1213-25. PMID:11183784
Page seeded by OCA on Thu Mar 20 10:19:59 2008
