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| - | {{STRUCTURE_4euq| PDB=4euq | SCENE= }}
| + | REMOVED: The PDB entry 4euq was removed. |
| - | ===The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the bound MART-1(26-35) peptide===
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| - | ==Disease==
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| - | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/MAR1_HUMAN MAR1_HUMAN]] Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.<ref>PMID:15695812</ref> <ref>PMID:19717472</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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| - | ==About this Structure==
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| - | [[4euq]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUQ OCA].
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| - | ==Reference==
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| - | <references group="xtra"/><references/>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Baker, B M.]]
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| - | [[Category: Hossain, M.]]
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| - | [[Category: Cancer]]
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| - | [[Category: Cross-reactivity]]
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| - | [[Category: Decapeptide]]
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| - | [[Category: Immune system]]
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| - | [[Category: Melanoma]]
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| - | [[Category: Mhc class i]]
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Current revision
REMOVED: The PDB entry 4euq was removed.
