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2ch8
From Proteopedia
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Revision as of 15:03, 30 October 2007
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STRUCTURE OF THE EPSTEIN-BARR VIRUS ONCOGENE BARF1
Overview
The Epstein-Barr virus is a human gamma-herpesvirus that persistently, infects more than 90% of the human population. It is associated with, numerous epithelial cancers, principally undifferentiated nasopharyngeal, carcinoma and gastric carcinoma. The BARF1 gene is expressed in a high, proportion of these cancers. An oncogenic, mitogenic and immortalizing, activity of the BARF1 protein has been shown. We solved the structure of, the secreted BARF1 glycoprotein expressed in a human cell line by X-ray, crystallography at a resolution of 2.3A. The BARF1 protein consists of two, immunoglobulin (Ig)-like domains. The N-terminal domain belongs to the, subfamily of variable domains whereas the C-terminal one is related to a, constant Ig-domain. BARF1 shows an unusual hexamerisation involving ... [(full description)]
About this Structure
2CH8 is a [Single protein] structure of sequence from [Human herpesvirus 4] with MAN and PT as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the Epstein-Barr virus oncogene BARF1., Tarbouriech N, Ruggiero F, de Turenne-Tessier M, Ooka T, Burmeister WP, J Mol Biol. 2006 Jun 9;359(3):667-78. Epub 2006 Apr 18. PMID:16647084
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