111d

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[[Image:111d.png|left|200px]]
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==CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS==
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<StructureSection load='111d' size='340' side='right' caption='[[111d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[111d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=111D FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=111d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=111d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=111d RCSB], [http://www.ebi.ac.uk/pdbsum/111d PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The synthetic dodecanucleotide d(CGCAAATTGGCG) has been analysed by single-crystal X-ray diffraction techniques and the structure refined to R = 0.16 and 2.25 A resolution, with the location of 94 solvent molecules. The sequence crystallizes as a full turn of a B-DNA helix with ten Watson-Crick base-pairs and two adenine-guanine mispairs. The analysis clearly shows that the mismatches are of the form A(anti).G(syn). Thermal denaturation studies indicate that the stability of the duplex is strongly pH dependent, with a maximum at pH 5.0, suggesting that the base-pair is stabilized by protonation. Three different arrangements have been observed for base-pairs between guanine and adenine and it is likely that A.G mismatch conformation is strongly influenced by dipole-dipole interactions with adjacent base-pairs.
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{{STRUCTURE_111d| PDB=111d | SCENE= }}
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Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs.,Brown T, Leonard GA, Booth ED, Chambers J J Mol Biol. 1989 May 20;207(2):455-7. PMID:2754734<ref>PMID:2754734</ref>
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===CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_2754734}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[111d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA].
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</StructureSection>
[[Category: Booth, E D.]]
[[Category: Booth, E D.]]
[[Category: Brown, T.]]
[[Category: Brown, T.]]

Revision as of 08:24, 23 July 2014

CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS

111d, resolution 2.25Å

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