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2cig

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[[Category: tuberculosis]]
[[Category: tuberculosis]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:10:25 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:09:11 2007''

Revision as of 15:04, 30 October 2007

Image:2cig.gif

2cig, resolution 1.90Å

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DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS INHIBITED BY THE ACYCLIC 4R ISOMER OF INH-NADP A DERIVATIVE OF THE PRODRUG ISONIAZID.

Overview

Isoniazid is a key drug used in the treatment of tuberculosis. Isoniazid, is a pro-drug, which, after activation by the katG-encoded catalase, peroxidase, reacts nonenzymatically with NAD(+) and NADP(+) to generate, several isonicotinoyl adducts of these pyridine nucleotides. One of these, the acyclic 4S isomer of isoniazid-NAD, targets the inhA-encoded enoyl-ACP, reductase, an enzyme essential for mycolic acid biosynthesis in, Mycobacterium tuberculosis. Here we show that the acyclic 4R isomer of, isoniazid-NADP inhibits the M. tuberculosis dihydrofolate reductase, (DHFR), an enzyme essential for nucleic acid synthesis. This biologically, relevant form of the isoniazid adduct is a subnanomolar bisubstrate, inhibitor of M. tuberculosis DHFR. Expression of M. tuberculosis DHFR in, ... [(full description)]

About this Structure

2CIG is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with SO4, 1DG and GOL as [ligands]. Active as [Dihydrofolate reductase], with EC number [1.5.1.3]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid., Argyrou A, Vetting MW, Aladegbami B, Blanchard JS, Nat Struct Mol Biol. 2006 May;13(5):408-13. Epub 2006 Apr 30. PMID:16648861

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