1d4n

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[[Image:1d4n.jpg|left|200px]]<br /><applet load="1d4n" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1d4n.jpg|left|200px]]
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caption="1d4n, resolution 2.00&Aring;" />
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'''HUMAN SERUM TRANSFERRIN'''<br />
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{{Structure
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|PDB= 1d4n |SIZE=350|CAPTION= <scene name='initialview01'>1d4n</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene> and <scene name='pdbligand=FE:FE (III) ION'>FE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HUMAN SERUM TRANSFERRIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1D4N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CO3:'>CO3</scene> and <scene name='pdbligand=FE:'>FE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4N OCA].
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1D4N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4N OCA].
==Reference==
==Reference==
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Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron., Yang AH, MacGillivray RT, Chen J, Luo Y, Wang Y, Brayer GD, Mason AB, Woodworth RC, Murphy ME, Protein Sci. 2000 Jan;9(1):49-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10739246 10739246]
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Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron., Yang AH, MacGillivray RT, Chen J, Luo Y, Wang Y, Brayer GD, Mason AB, Woodworth RC, Murphy ME, Protein Sci. 2000 Jan;9(1):49-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10739246 10739246]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferrin]]
[[Category: transferrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:12:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:32:50 2008''

Revision as of 08:32, 20 March 2008

Image:1d4n.jpg


PDB ID 1d4n

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



HUMAN SERUM TRANSFERRIN


Contents

Overview

The X-ray crystallographic structures of two mutants (K206Q and H207E) of the N-lobe of human transferrin (hTF/2N) have been determined to high resolution (1.8 and 2.0 A, respectively). Both mutant proteins bind iron with greater affinity than native hTF/2N. The structures of the K206Q and H207E mutants show interactions (both H-bonding and electrostatic) that stabilize the interaction of Lys296 in the closed conformation, thereby stabilizing the iron bound forms.

Disease

Known diseases associated with this structure: Atransferrinemia OMIM:[190000], Iron deficiency anemia, susceptibility to OMIM:[190000]

About this Structure

1D4N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron., Yang AH, MacGillivray RT, Chen J, Luo Y, Wang Y, Brayer GD, Mason AB, Woodworth RC, Murphy ME, Protein Sci. 2000 Jan;9(1):49-52. PMID:10739246

Page seeded by OCA on Thu Mar 20 10:32:50 2008

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OCA

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