Deaminase

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<StructureSection load='1aln' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''>
<StructureSection load='1aln' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''>
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'''Deaminase''' removes an amine group from a molecule. '''Cytosine deaminase''' (CDDA) converts cytosine to uracil. '''Cytidine deaminase''' (CDDA) converts cytidine to uridine. 5-methylcytosine deaminase (MCDA) produces thymine. '''Guanine deaminase''' (GDA) converts guanine to xanthine. '''Adenine deaminase''' (ADA) converts adenine to hypoxanthine.
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'''Deaminase''' removes an amine group from a molecule. <br />
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* '''Cytosine deaminase''' (CDA) converts cytosine to uracil. <br />
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* '''Cytidine deaminase''' (CDDA) converts cytidine to uridine. <br />
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* '''5-methylcytosine deaminase''' (MCDA) produces thymine. <br />
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* '''Guanine deaminase''' (GDA) converts guanine to xanthine. <br />
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* '''Adenine deaminase''' (ADA) converts adenine to hypoxanthine.<br />
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* '''Glucosamine 6-phosphate deaminase''' (GPD) converts glucosamine 6-phosphate to fructose 6-phosphate.<br />
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* '''1-aminocyclopropane-1-carboxylate deaminase''' (ACCD) converts 1-aminocyclopropane-1-carboxylic acid to 2-oxobutyrate.<br />
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* '''dCTP deaminase''' (ADA) converts dCTP to dUTP.<br />
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* '''dCTP deaminase-dUTPase''' (DCD-DUT) converts dCTP to dUMP.<br />
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* '''Blasticidin-S deaminase''' (BSD) converts blasticidin-S to deaminohydroxyblasticidin.<br />
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* '''Threonine deaminase''' (THD) converts L-threonine to α-ketobutyrate.<br />
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* '''L-serine deaminase''' (LSD) converts L-serine to pyruvate.<br />
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* '''D-serine deaminase''' (DSD) converts D-serine to pyruvate.<br />
== 3D Structures of deaminase ==
== 3D Structures of deaminase ==
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[[2d30]] – CDA – ''Bacillus anthracis'' <BR />
[[2d30]] – CDA – ''Bacillus anthracis'' <BR />
[[3dmo]] – CDA – ''Burkholderia pseudomallei'' <BR />
[[3dmo]] – CDA – ''Burkholderia pseudomallei'' <BR />
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[[3ijf]] – CDA – ''Mycobacterium tuberculosis'' <BR />
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[[3ijf]] – MtCDA – ''Mycobacterium tuberculosis'' <BR />
[[3mpz]] – CDA – ''Mycobacterium smegmatis'' <BR />
[[3mpz]] – CDA – ''Mycobacterium smegmatis'' <BR />
[[3r2n]] – CDA – ''Mycobacterium leprae'' <BR />
[[3r2n]] – CDA – ''Mycobacterium leprae'' <BR />
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See [[Adenosine deaminase]]
See [[Adenosine deaminase]]
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'''Glucosamine 6-phosphate deaminase'''
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[[1dea]], [[1cd5]], [[1fs6]], [[1fsf]] – EcGPD <BR />
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[[1jt9]] – EcGPD (mutant) <BR />
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[[2ri0]] – SmGPD – ''Streptococcus mutans'' <BR />
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[[3hns]] – GPD – ''Borrelia burgdorferi''<br />
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[[1hor]] – EcGPD + deoxy-amino glucitol-phosphate<BR />
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[[1hot]], [[1frz]], [[1fs5]], [[2wu1]] – EcGPD + N-acetyl-glucosamine-6-phosphate<BR />
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[[1fqo]] – EcGPD + fructose 6-phosphate<BR />
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[[2ri1]] – SmGPD + glucosamine-6-phosphate<BR />
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'''1-aminocyclopropane-1-carboxylate (ACC) deaminase'''
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[[1f2d]] – WsACCD + PLP – ''Williopsis saturnus''<BR />
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[[1j0c]] – WsACCD (mutant) + PLP <BR />
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[[1j0d]] – WsACCD (mutant) + inhibitor<BR />
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[[1j0e]] – WsACCD (mutant) + PLP + ACC<BR />
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[[1j0a]] – PhACCD + PLP + 2-propanol – ''Pyrococcus horikoshii''<BR />
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[[1j0b]] – PhACCD + inhibitor<BR />
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[[1tyz]] – PsACCD + PLP - ''Pseudomonas''<BR />
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[[1rqx]] – PsACCD + PLP + inhibitor <BR />
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[[1tz2]] – PsACCD + PLP + ACC<BR />
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[[1tzj]] – PsACCD + PLP + vinylglycine<BR />
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[[1tzk]] – PsACCD + PLP + α-ketobutyrate<BR />
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[[1tzm]] – PsACCD + PLP + chloroalanine<BR />
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'''dCTP deaminase'''
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[[2qlp]] – MtCTPD <BR />
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[[3km3]] – CTPD – ''Anaplasma phagocytophilum''<br />
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[[4dhk]] – CTPD - ''Burkholderia thailandensis''<BR />
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''dCTP deaminase complex''
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[[1xs1]] – EcCTPD + dUTP<BR />
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[[1xs4]] – EcCTPD (mutant) + dCTP<BR />
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[[2j4h]] – EcCTPD (mutant) + dCDP<BR />
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[[1xs6]], [[2v9x]] – EcCTPD (mutant) + dUTP<BR />
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[[2j4q]] – EcCTPD (mutant) + dTTP + dTDP<BR />
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[[2qxx]] – MtCTPD + dTTP<BR />
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'''dCTP deaminase-dUTPase'''
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[[2hxb]], [[1ogh]], [[1pkh]], [[3gf0]] – MjDCD-DUT – ''Methanocaldococcus jannaschii'' <BR />
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[[1pkj]] – MjDCD-DUT + dUTP<BR />
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[[2hxd]] – MjDCD-DUT (mutant) + dUTP derivative<BR />
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[[1pkk]] – MjDCD-DUT + dCTP<BR />
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'''Porphobilinogen deaminase'''
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See [[Porphobilinogen Deaminase]]
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'''Blasticidin-S deaminase'''
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[[1wn5]], [[2z3g]] – AtBSD – ''Aspergillus terreus'' <BR />
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[[2z3j]] – AtBSD (mutant) <BR />
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[[3oj6]] – BSD – Coccidioides immitis <BR />
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[[1wn6]] – AtBSD + blasticidin-S intermediate<BR />
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[[2z3h]] – AtBSD + deaminohydroxy blasticidin-S <BR />
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[[2z3i]] – AtBSD (mutant) + blasticidin-S <BR />
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'''Threonine deaminase'''
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[[1tdj]] – EcTHD + PLP <BR />
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[[2gn0]], [[2gn1]] – StTHD + PLP derivative – ''Salmonella typhimurium''<BR />
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[[2gn2]] – StTHD + PLP derivative + CMP<BR />
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[[3iau]] – THD + PLP derivative – tomato<BR />
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'''L-serine deaminase'''
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[[1pwe]] – rLSD - rat <BR />
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[[1p5j]], [[2rkb]] – hLSD (mutant) + PLP <BR />
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[[1pwh]] – rLSD + PLP derivative <BR />
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'''D-serine deaminase'''
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[[3r0x]], [[3r0z]] – DSD – ''Salmonella enterica''<BR />
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[[3ss7]], [[3ss9]] – EcDSD + PLP <BR />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:43, 31 July 2014

Structure of cytidine deaminase complex with deazacytosine (PDB entry 1aln)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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