Neutrophil gelatinase-associated lipocalin

Function

Neutrophil gelatinase-associated lipocalin (NGAL) or lipocalin-2 is involved in innate immunity by sequestering bacterial iron and thus preventing bacterial growth.

Disease

Relevance

NGAL is secreted in high levels into the blood following acute kidney injury and thus can be used as a biomarker for it.

Structural highlights

3D structures of neutrophil gelatinase-associated lipocalin

Updated on 06-August-2014

1dfv, 1qqs – hNGAL – human

3dtq – hNGAL (mutant)
1ngl – hNGAL - NMR
2k23 – NGAL – rat - NMR
3s26 – NGAL – mouse

Neutrophil gelatinase-associated lipocalin complex

1l6m – hNGAL (mutant) + Fe+3
3pec – hNGAL + Fe+3 + carboxymycobactin
1x71, 1x89, 1x8u – hNGAL (mutant) + Fe+3 + carboxymycobactin
3by0, 3cbc, 3cmp, 3hwd, 3hwf, 3hwg, 3i0a, 3k3l, 3t1d – hNGAL (mutant) + Fe+3 + enterobactin
3tf6 – hNGAL (mutant) + Eu+2+ enterobactin
3fw4, 3fw5 – hNGAL (mutant) + Fe+3 + catechol derivative
3cmp, 3hwe – hNGAL (mutant) + Fe+3 + bishacam
3dsz – hNGAL + Yt+3 + DTPA

References