1d91
From Proteopedia
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| - | [[Image:1d91.gif|left|200px]] | + | [[Image:1d91.gif|left|200px]] |
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| - | '''G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)''' | + | {{Structure |
| + | |PDB= 1d91 |SIZE=350|CAPTION= <scene name='initialview01'>1d91</scene>, resolution 2.100Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1D91 is a [ | + | 1D91 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D91 OCA]. |
==Reference== | ==Reference== | ||
| - | G . T base-pairs in a DNA helix: the crystal structure of d(G-G-G-G-T-C-C-C)., Kneale G, Brown T, Kennard O, Rabinovich D, J Mol Biol. 1985 Dec 20;186(4):805-14. PMID:[http:// | + | G . T base-pairs in a DNA helix: the crystal structure of d(G-G-G-G-T-C-C-C)., Kneale G, Brown T, Kennard O, Rabinovich D, J Mol Biol. 1985 Dec 20;186(4):805-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/4093986 4093986] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Brown, T.]] | [[Category: Brown, T.]] | ||
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[[Category: mismatched]] | [[Category: mismatched]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:34:48 2008'' |
Revision as of 08:34, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)
Overview
The synthetic deoxyoctanucleotide d(G-G-G-G-T-C-C-C) crystallizes as an A-type DNA double helix containing two adjacent G . T base-pair mismatches. The structure has been refined to an R-factor of 14% at 2.1 A resolution with 104 solvent molecules located. The two G . T mismatches adopt the "wobble" form of base-pairing. The mismatched bases are linked by a network of water molecules interacting with the exposed functional groups in both the major and minor grooves. The presence of two mispaired bases in the octamer has surprisingly little effect on the global structure of the helix or the backbone and glycosidic torsional angles. Base stacking around the mismatch is perturbed, but the central G-T step shows particularly good base overlap, which may contribute to the relatively high stability of this oligomer.
About this Structure
1D91 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
G . T base-pairs in a DNA helix: the crystal structure of d(G-G-G-G-T-C-C-C)., Kneale G, Brown T, Kennard O, Rabinovich D, J Mol Biol. 1985 Dec 20;186(4):805-14. PMID:4093986
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