|
|
| Line 17: |
Line 17: |
| | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
| | | | |
| - | [[1ahj]], [[2cyz]], [[2cz0]], [[2cz1]] – ReNH α,β subunits + Fe – ''Rhodococcus erythropolis''<br />
| + | ===Fe-containing nitrile hydratase=== |
| - | [[2czf]], [[3a8l]] – ReNH α (mutant),β subunits + Fe <br />
| + | |
| | | | |
| - | ===Nitrile hydratase complex===
| + | [[1ahj]], [[2cyz]], [[2cz0]], [[2cz1]] – ReNH α,β subunits – ''Rhodococcus erythropolis''<br /> |
| | + | [[2czf]], [[3a8l]] – ReNH α (mutant),β subunits <br /> |
| | + | [[4fm4]] – NH α,β subunits – ''Comamonas testosteroni''<br /> |
| | | | |
| - | [[2ahj]] – ReNH α,β subunits + Fe + NO2<br />
| + | ''Nitrile hydratase complex'' |
| - | [[2cz6]], [[2d0q]] – ReNH α,β subunits + Fe + cyclohexyl isocyanate<br />
| + | |
| - | [[2cz7]], [[2zpb]] – ReNH α,β subunits + Fe + NO<br />
| + | |
| - | [[2qdy]] – ReNH α,β subunits + Fe + isobutyronitrile<br />
| + | |
| - | [[2zpe]], [[2zpg]], [[2zph]], [[2zpi]] – ReNH α,β subunits + Fe + tert-butyl isocyanate<br />
| + | |
| - | [[2zpf]] – ReNH α,β subunits + Fe + tert-butyl isocyanate + NO<br />
| + | |
| - | [[3a8o]] – ReNH α,β subunits + Fe + trimethyl acetonitrile <br />
| + | |
| - | [[3a8g]] – ReNH α (mutant),β subunits + Fe + trimethyl acetonitrile + NO <br />
| + | |
| - | [[3a8h]] – ReNH α (mutant),β subunits + Fe + trimethyl acetonitrile <br />
| + | |
| - | [[3a8m]] – ReNH α,β (mutant) subunits + Fe + trimethyl acetonitrile <br />
| + | |
| | | | |
| | + | [[2ahj]] – ReNH α,β subunits + NO2<br /> |
| | + | [[2cz6]], [[2d0q]] – ReNH α,β subunits + cyclohexyl isocyanate<br /> |
| | + | [[2cz7]], [[2zpb]] – ReNH α,β subunits + NO<br /> |
| | + | [[2qdy]] – ReNH α,β subunits + isobutyronitrile<br /> |
| | + | [[2zpe]], [[2zpg]], [[2zph]], [[2zpi]] – ReNH α,β subunits + tert-butyl isocyanate<br /> |
| | + | [[2zpf]] – ReNH α,β subunits + tert-butyl isocyanate + NO<br /> |
| | + | [[3a8o]] – ReNH α,β subunits + trimethyl acetonitrile <br /> |
| | + | [[3a8g]] – ReNH α (mutant),β subunits + trimethyl acetonitrile + NO <br /> |
| | + | [[3a8h]] – ReNH α (mutant),β subunits + trimethyl acetonitrile <br /> |
| | + | [[3a8m]] – ReNH α,β (mutant) subunits + trimethyl acetonitrile <br /> |
| | + | |
| | + | ===Co-containing nitrile hydratase=== |
| | + | |
| | + | [[1ire]], [[1ugq]] – PtNH α,β subunits – ''Pseudonocardia thermophila''<br /> |
| | + | [[1ugr]], [[1ugs]], [[3vyh]] – PtNH α (mutant),β subunits <br /> |
| | + | [[1v29]] – NH α,β subunits – ''Bacillus smithii''<br /> |
| | + | [[2dpp]] – NH α,β subunits – ''Bacillus'' <br /> |
| | + | [[3hht]] – NH α (mutant),β (mutant) subunits – ''Geobacillus palilidus''<br /> |
| | + | [[1ugp]] – PtNH α,β subunits + butyrate<br /> |
| | | | |
| | == References == | | == References == |
|
Function
Nitrile hydratase (NH) catalyze the hydration of nitriles to amides. NH contains Fe or Co ion in its active site. NH consists of two subunits: α and β and exists as dimer or tetramer with one metal ion bound per dimer.
Disease
Relevance
Nitrile hydratase is used industrially in the production of acrylamide and nicotinamide.
Structural highlights
3D structures of nitrile hydratase
Updated on 13-August-2014
Fe-containing nitrile hydratase
1ahj, 2cyz, 2cz0, 2cz1 – ReNH α,β subunits – Rhodococcus erythropolis
2czf, 3a8l – ReNH α (mutant),β subunits
4fm4 – NH α,β subunits – Comamonas testosteroni
Nitrile hydratase complex
2ahj – ReNH α,β subunits + NO2
2cz6, 2d0q – ReNH α,β subunits + cyclohexyl isocyanate
2cz7, 2zpb – ReNH α,β subunits + NO
2qdy – ReNH α,β subunits + isobutyronitrile
2zpe, 2zpg, 2zph, 2zpi – ReNH α,β subunits + tert-butyl isocyanate
2zpf – ReNH α,β subunits + tert-butyl isocyanate + NO
3a8o – ReNH α,β subunits + trimethyl acetonitrile
3a8g – ReNH α (mutant),β subunits + trimethyl acetonitrile + NO
3a8h – ReNH α (mutant),β subunits + trimethyl acetonitrile
3a8m – ReNH α,β (mutant) subunits + trimethyl acetonitrile
Co-containing nitrile hydratase
1ire, 1ugq – PtNH α,β subunits – Pseudonocardia thermophila
1ugr, 1ugs, 3vyh – PtNH α (mutant),β subunits
1v29 – NH α,β subunits – Bacillus smithii
2dpp – NH α,β subunits – Bacillus
3hht – NH α (mutant),β (mutant) subunits – Geobacillus palilidus
1ugp – PtNH α,β subunits + butyrate
References
|
