Dioxygenase

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<StructureSection load='1eob' size='350' side='right' caption='Structure of protocatechuate 3,4-dioxygenase with Fe+3 complex with dihydroxybenzoate (PDB entry [[1eob]])' scene=''>
<StructureSection load='1eob' size='350' side='right' caption='Structure of protocatechuate 3,4-dioxygenase with Fe+3 complex with dihydroxybenzoate (PDB entry [[1eob]])' scene=''>
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'''Dioxygenases''' cleave the aromatic rings of their substrates by inserting two oxygen atoms, thus degrading these compounds. The dioxygenases are divided into 2 groups according to their mode of ring scission. The intradiol enzymes use Fe+3 as cofactor and cleave the substrate between 2 hydroxyl groups. The extradiol enzymes use Fe+2 as cofactor and cleave the substrate between a hydroxylated carbon and a non-hydroxylated one. '''Protocatechuate 3,4-dioxygenase''' (PCD), belongs to the intradiol family and catalyzes the oxygenation of dihydroxybenzoate (DHB) to 3-carboxy-muconate. PCD participates in the aromatic compound benzoate degredation and uses Fe as cofactor. PCD consists of 8 subunits each containing an Fe and a substrate binding site. Each of these subunits is composed of α and β chains. Hydroxyphenyl acetate is an inhibitor of PCD. '''Catechol 1,2-dioxygenase''' (CTD) cleaves the ring of catechol by insertion of 2 oxygen atoms to form muconic acid. '''Homoprotocatechuate 3,4-dioxygenase''' (HPCD), an extradiol cleaving enzyme cleaves the aromatic ring of its substrate, adds 2 oxygen atoms to form α-hydroxy-δ carboxymethyl muconic semialdehyde. '''Naphthalene 1,2-dioxygenase''' (NDO) catalyzes the conversion of naphthalene and O2 to dihydronaphthalene-diol.
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'''Dioxygenases''' cleave the aromatic rings of their substrates by inserting two oxygen atoms, thus degrading these compounds. The dioxygenases are divided into 2 groups according to their mode of ring scission. The intradiol enzymes use Fe+3 as cofactor and cleave the substrate between 2 hydroxyl groups. The extradiol enzymes use Fe+2 as cofactor and cleave the substrate between a hydroxylated carbon and a non-hydroxylated one. <br />
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* '''Protocatechuate 3,4-dioxygenase''' (PCD), belongs to the intradiol family and catalyzes the oxygenation of dihydroxybenzoate (DHB) to 3-carboxy-muconate. PCD participates in the aromatic compound benzoate degredation and uses Fe as cofactor. PCD consists of 8 subunits each containing an Fe and a substrate binding site. Each of these subunits is composed of α and β chains. Hydroxyphenyl acetate is an inhibitor of PCD.<br />
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* '''Catechol 1,2-dioxygenase''' (CTD) cleaves the ring of catechol by insertion of 2 oxygen atoms to form muconic acid.<br />
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* '''Homoprotocatechuate 3,4-dioxygenase''' (HPCD), an extradiol cleaving enzyme cleaves the aromatic ring of its substrate, adds 2 oxygen atoms to form α-hydroxy-δ carboxymethyl muconic semialdehyde.<br />
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* '''Naphthalene 1,2-dioxygenase''' (NDO) catalyzes the conversion of naphthalene and O2 to dihydronaphthalene-diol.
==3D structures of Protocatechuate 3,4-dioxygenase==
==3D structures of Protocatechuate 3,4-dioxygenase==

Revision as of 10:39, 17 August 2014

Structure of protocatechuate 3,4-dioxygenase with Fe+3 complex with dihydroxybenzoate (PDB entry 1eob)

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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