This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Ephrin receptor
From Proteopedia
| Line 3: | Line 3: | ||
'''Ephrin receptors''' (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3). For more details see [[ Ephrin Type-A Receptor]]. | '''Ephrin receptors''' (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3). For more details see [[ Ephrin Type-A Receptor]]. | ||
| - | |||
| - | {{TOC limit|limit=2}} | ||
| - | |||
| - | |||
| - | |||
== 3D Structures of ephrin receptors == | == 3D Structures of ephrin receptors == | ||
Revision as of 06:32, 18 August 2014
Ephrin receptors (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3). For more details see Ephrin Type-A Receptor.
Contents |
3D Structures of ephrin receptors
Updated on 18-August-2014
Ephrin A1 receptor
3kka - hEPH A1 SAM+ hEPH A2 SAM – human
3hil - hEPH A1 SAM
2k1l - hEPH A1 transmembrane domain – NMR
1x5a - hEPH A1 fn3 domain – NMR
Ephrin A2 receptor
3hpn, 3c8x - hEPH A2 LBD
2x10, 3fl7 - hEPH A2 ectodomain
2k9y, 2e8n - hEPH A2 transmembrane domain – NMR
1mqb - hEPH A2 kinase domain
Ephrin A2 receptor binary complex
3mx0, 2x11 - hEPH A2 ectodomain + ephrin A5
3hei, 3czu - hEPH A2 LBD + ephrin A1
3mbw - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1
2kso - hEPH A2 SAM + SHIP2
Ephrin A3 receptor
2qo2, 2qob, 2gsf - hEPH A3 kinase domain
2qok, 2qol, 2qon, 2qoo, 2qod, 2qof, 2qoi - hEPH A3 kinase domain (mutant)
3fxx, 3fy2 – hEPH A3 kinase domain + peptide substrate
2qoq, 2qo7, 2qo9, 2qoc - hEPH A3 kinase domain + AMP-PNP
3dzq - hEPH A3 kinase domain + inhibitor
4g2f - hEPH A3 kinase domain (mutant) + inhibitor
Ephrin A4 receptor
2wo1, 3ckh - hEPH A4 LBD
4bk4, 4m4p - hEPH A4 ectodomain
2lw8 - hEPH A4 LBD – NMR
2hel – mEPH A4 membrane and kinase domains – mouse
2y6m – mEPH A4 kinase domain
Ephrin A4 receptor binary complex
2wo3 - hEPH A4 LBD + ephrin A2 receptor-binding domain
2wo2, 3gxu - hEPH A4 LBD + ephrin B2 receptor-binding domain
4bk5, 4bka, 4m4r - hEPH A4 ectodomain + ephrin A5 LBD
4bkf - hEPH A4 ectodomain + ephrin B3 LBD
2xyu – mEPH A4 kinase domain + inhibitor
2y6o – mEPH A4 kinase domain + cancer drug
Ephrin A5 receptor
2r2p - hEPH A5 kinase domain
1shx - mEPH A5
4et7 – hEPH A5 (mutant)
Ephrin A7 receptor
3nru – hEPH A7 LBD
3h8m – hEPH A7 SAM
2rei - hEPH A7 kinase domain
3dko – hEPH A7 kinase domain + inhibitor
Ephrin A8 receptor
3kul - hEPH A8 kinase domain
1x5l – hEPH A8 fn3 domain – NMR
1ucv - hEPH A8 SAM – NMR
Ephrin B1 receptor
2eao – hEPH B1 SAM – NMR
2djs - hEPH B1 fn3 domain – NMR
3zfx - hEPH B1 kinase domain
Ephrin B2 receptor
3etp – hEPH B2
1f0m – mEPH B2 SAM
1iko - mEPH B2 ectodomain
2i85 - hEPH B2 ectodomain
1sgg - mEPH B2 SAM – chicken - NMR
Ephrin B2 receptor binary complex
2vsk, 2vsm – hEPH B2 + Viral Hemagglutinin-neuraminidase
2qbx – hEPH B2 + peptide agonist
2hen - hEPH B2 kinase domain + ADP
1shw - mEPH B2 LBD + ephrin A5
1kgy - mEPH B2 LBD + ephrin B2 extracellular domain
Ephrin B3 receptor
3p1i – hEPH B3 LBD
3zfy - hEPH B3 kinase domain
Ephrin B4 receptor
2qkq – hEPH B4 SAM
2e7h – hEPH B4 fn3 domain - NMR
2x9f, 2vwy - hEPH B4 kinase domain (mutant)
Ephrin B4 receptor binary complex
2vwx, 2vwz, 2vx0, 2vx1, 2vwu, 2vwv, 2vww, 4aw5 – hEPH B4 kinase domain + inhibitor
3zew - hEPH B4 + staurosporine
2xvd, 2yn8, 4bb4 - hEPH B4 kinase domain (mutant) + inhibitor
2hle, 2bba - hEPH B4 LBD + ephrin B2
