Interleukin receptor
From Proteopedia
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| - | {{STRUCTURE_2b5i| PDB=2b5i | SIZE=400| SCENE= |right|CAPTION= | + | {{STRUCTURE_2b5i| PDB=2b5i | SIZE=400| SCENE= |right|CAPTION=Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]] }} |
'''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and . ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to typew I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). | '''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and . ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to typew I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | + | ===Interleukin receptor type I=== | |
| - | + | ===Interleukin-2 receptor=== | |
[[1z92]] – hIL2R α subunit + interleukin-2<br /> | [[1z92]] – hIL2R α subunit + interleukin-2<br /> | ||
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[[3iu3]], [[3nfp]] - hIL2R α subunit + antibody | [[3iu3]], [[3nfp]] - hIL2R α subunit + antibody | ||
| - | + | ===Interleukin-4 receptor=== | |
[[1iar]] - hIL4R α (mutant) subunit + interleukin-4<br /> | [[1iar]] - hIL4R α (mutant) subunit + interleukin-4<br /> | ||
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[[3bpo]] - hIL4R α subunit + hIL13R α subunit + interleukin-13 | [[3bpo]] - hIL4R α subunit + hIL13R α subunit + interleukin-13 | ||
| - | + | ===Interleukin-5 receptor=== | |
[[3qt2]] – hIL5R α (mutant) subunit + interleukin-5<br /> | [[3qt2]] – hIL5R α (mutant) subunit + interleukin-5<br /> | ||
[[3va2]] - hIL5R α subunit + interleukin-5<br /> | [[3va2]] - hIL5R α subunit + interleukin-5<br /> | ||
| - | + | ===Interleukin-6 receptor or gp130=== | |
[[1i1r]] – hIL6R β subunit + interleukin-6 homolog<br /> | [[1i1r]] – hIL6R β subunit + interleukin-6 homolog<br /> | ||
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[[1p9m]] - hIL6R α + β subunits + interleukin-6 | [[1p9m]] - hIL6R α + β subunits + interleukin-6 | ||
| - | + | ===Interleukin-7 receptor=== | |
[[3up1]] - hIL7R α subunit<br /> | [[3up1]] - hIL7R α subunit<br /> | ||
[[3di2]], [[3di3]] – hIL7R α (mutant) subunit + interleukin-7 (mutant) | [[3di2]], [[3di3]] – hIL7R α (mutant) subunit + interleukin-7 (mutant) | ||
| - | + | ===Interleukin-13 receptor=== | |
[[3lb6]] - hIL13R α2 (mutant) subunit + interleukin-13<br /> | [[3lb6]] - hIL13R α2 (mutant) subunit + interleukin-13<br /> | ||
[[4hwb]] - hIL13R α1 subunit + antibody<br /> | [[4hwb]] - hIL13R α1 subunit + antibody<br /> | ||
| - | + | ===Interleukin-15 receptor=== | |
[[2ers]] - hIL15R α subunit sushIL domain – NMR<br /> | [[2ers]] - hIL15R α subunit sushIL domain – NMR<br /> | ||
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[[4gs7]] - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits<br /> | [[4gs7]] - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits<br /> | ||
| - | + | ===Interleukin-17 receptor=== | |
[[3jvf]] - hIL17RA extracellular domain + interleukin-17F<br /> | [[3jvf]] - hIL17RA extracellular domain + interleukin-17F<br /> | ||
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[[3vbc]] – mIL17RB<br /> | [[3vbc]] – mIL17RB<br /> | ||
| - | + | ===Interleukin-21 receptor=== | |
[[3tgx]] – hIL21R extracellular domain (mutant) + interleukin-21 | [[3tgx]] – hIL21R extracellular domain (mutant) + interleukin-21 | ||
| - | + | ===Interleukin receptor type II=== | |
| - | + | ===Interleukin-10 receptor=== | |
[[1j7v]] – hIL10R α (mutant) subunit + interleukin-10<br /> | [[1j7v]] – hIL10R α (mutant) subunit + interleukin-10<br /> | ||
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[[3lqm]] - hIL10R β (mutant) subunit | [[3lqm]] - hIL10R β (mutant) subunit | ||
| - | + | ===Interleukin-20 receptor=== | |
[[4doh]] - hIL20R α,β subunit + interleukin-20<br /> | [[4doh]] - hIL20R α,β subunit + interleukin-20<br /> | ||
| - | + | ===Interleukin-22 receptor=== | |
[[3g9v]] - hIL22R α subunit + interleukin-22<br /> | [[3g9v]] - hIL22R α subunit + interleukin-22<br /> | ||
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[[3dlq]] - hIL22R α (mutant) subunit + interleukin-2 (mutant) | [[3dlq]] - hIL22R α (mutant) subunit + interleukin-2 (mutant) | ||
| - | + | ===Interleukin-28 receptor=== | |
[[3og4]], [[3og6]] - hIL28R α subunit + interleukin-29<br /> | [[3og4]], [[3og6]] - hIL28R α subunit + interleukin-29<br /> | ||
| - | + | ===Interleukin receptor of immunoglobulin family=== | |
| - | + | ===Interleukin-1 receptor (CD121a, CD121b)=== | |
[[1itb]] – hI1R1 extracellular domain + interleukin-1 β – human<br /> | [[1itb]] – hI1R1 extracellular domain + interleukin-1 β – human<br /> | ||
Revision as of 06:49, 19 August 2014
Template:STRUCTURE 2b5i Interleukin receptors (ILR) are cytokine receptor which are classified into type I, type II and . ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to typew I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).
3D structures of interleukin receptor
Updated on 19-August-2014
Interleukin receptor type I
Interleukin-2 receptor
1z92 – hIL2R α subunit + interleukin-2
2b5i - hIL2R α+β+γ subunits + interleukin-2
3qaz - hIL2R β+γ subunits + interleukin-2
2erj - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)
3qb7 - hIL2R γ (mutant) subunit + interleukin-2
3iu3, 3nfp - hIL2R α subunit + antibody
Interleukin-4 receptor
1iar - hIL4R α (mutant) subunit + interleukin-4
3bpl - hIL4R α + γ subunits + interleukin-4
3bpn - hIL4R α subunit + hIL13R α subunit + interleukin-4
3bpo - hIL4R α subunit + hIL13R α subunit + interleukin-13
Interleukin-5 receptor
3qt2 – hIL5R α (mutant) subunit + interleukin-5
3va2 - hIL5R α subunit + interleukin-5
Interleukin-6 receptor or gp130
1i1r – hIL6R β subunit + interleukin-6 homolog
1pvh - hIL6R β subunit + leukemia inhILbitory factor
2hmh - mI6R β subunit + suppressor of cytokine signaling 3 – mouse
4gl9 - mI6R β subunit + suppressor of cytokine signaling 3 + tyrosine-protein kinase
3l5i, 3l5j, 3l5h - hIL6R β subunit
1n26 - hIL6R α subunit
2arw - hIL6R α subunit - NMR
1p9m - hIL6R α + β subunits + interleukin-6
Interleukin-7 receptor
3up1 - hIL7R α subunit
3di2, 3di3 – hIL7R α (mutant) subunit + interleukin-7 (mutant)
Interleukin-13 receptor
3lb6 - hIL13R α2 (mutant) subunit + interleukin-13
4hwb - hIL13R α1 subunit + antibody
Interleukin-15 receptor
2ers - hIL15R α subunit sushIL domain – NMR
2z3q, 2z3r, 2psm - hIL15R α subunit + interleukin-15
4gs7 - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits
Interleukin-17 receptor
3jvf - hIL17RA extracellular domain + interleukin-17F
4hsa - hIL17RA (mutant) + interleukin-17A
3vbc – mIL17RB
Interleukin-21 receptor
3tgx – hIL21R extracellular domain (mutant) + interleukin-21
Interleukin receptor type II
Interleukin-10 receptor
1j7v – hIL10R α (mutant) subunit + interleukin-10
1lqs, 1y6m, 1y6n - hIL10R α (mutant) subunit + interleukin-10 homolog
1y6k - hIL10R α (mutant) subunit + interleukin-10
3lqm - hIL10R β (mutant) subunit
Interleukin-20 receptor
4doh - hIL20R α,β subunit + interleukin-20
Interleukin-22 receptor
3g9v - hIL22R α subunit + interleukin-22
3dgc – hIL22R α (mutant) subunit + interleukin-22
3dlq - hIL22R α (mutant) subunit + interleukin-2 (mutant)
Interleukin-28 receptor
3og4, 3og6 - hIL28R α subunit + interleukin-29
Interleukin receptor of immunoglobulin family
Interleukin-1 receptor (CD121a, CD121b)
1itb – hI1R1 extracellular domain + interleukin-1 β – human
1ira- hI1R1 extracellular domain + I1R1A
1g0y - hI1R1 extracellular domain + I1R1A peptide
3o4o - hI1R2 + interleukin-1 β
4dep – hIL1R1 extracellular domain + interleukin-1 β + + interleukin-1 accessory protein
4gaf – hIL1R1 extracellular domain + IL1β/IL1RA
