Plasminogen activator

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 5: Line 5:
{{TOC limit|limit=2}}
{{TOC limit|limit=2}}
-
===3D structures of plasminogen activator===
+
==3D structures of plasminogen activator==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Line 12: Line 12:
[[1bqy]] – PLA – Pit viper
[[1bqy]] – PLA – Pit viper
-
==Tissue plasminogen activator==
+
===Tissue plasminogen activator===
[[1a5h]] – hTPA HC+LC + benzamidine – human<br />
[[1a5h]] – hTPA HC+LC + benzamidine – human<br />
Line 23: Line 23:
[[1tpm]], [[1tpn]] - hTPA fibrin-binding domain – NMR
[[1tpm]], [[1tpn]] - hTPA fibrin-binding domain – NMR
-
==Urokinase-type plasminogen activator==
+
===Urokinase-type plasminogen activator===
[[Urokinase]]
[[Urokinase]]
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 06:49, 20 August 2014

Template:STRUCTURE 1a5h

Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. It includes Tissue PLA (TPA) which is involved in breakdown of blood clots and urokinase-type PLA Urokinase. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.

Contents

3D structures of plasminogen activator

Updated on 20-August-2014

1a5i – PLA residues 213-477 + EGR-CMK – Vampire bat
1bqy – PLA – Pit viper

Tissue plasminogen activator

1a5h – hTPA HC+LC + benzamidine – human
1rtf - hTPA HC+LC
1tpg – hTPA F1-G - NMR
1bda – hTPA catalytic domain (mutant) + EGR-CMK
1pk2 – hTPA kringle 2 domain + 6-aminohexanoic acid – NMR
1tpk, 1pml - hTPA kringle 2 domain
1kdu - hTPA kringle domain – NMR
1tpm, 1tpn - hTPA fibrin-binding domain – NMR

Urokinase-type plasminogen activator

Urokinase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Personal tools