4nzl

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'''Unreleased structure'''
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==Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases==
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<StructureSection load='4nzl' size='340' side='right' caption='[[4nzl]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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The entry 4nzl is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZL FirstGlance]. <br>
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Authors: Stapels, D.A.C., von Koeckritz-Blickwede, M., Ramyar, K.X., Bischoff, M., Milder, F., Ruyken, M., Scheepmaker, L., McWhorter, W.J., Herrmann, M., van Kessel, K.P.M., Geisbrecht, B.V., Rooijakkers, S.H.M.
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>
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Description: Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum]</span></td></tr>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[http://omim.org/entry/162800 162800]]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref> Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[http://omim.org/entry/202700 202700]]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Leukocyte elastase]]
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[[Category: Bischoff, M.]]
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[[Category: Geisbrecht, B V.]]
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[[Category: Herrmann, M.]]
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[[Category: Kessel, K P.M van.]]
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[[Category: Koeckritz-Blickwede, M von.]]
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[[Category: McWhorter, W J.]]
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[[Category: Milder, F.]]
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[[Category: Ramyar, K X.]]
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[[Category: Rooijakkers, S H.M.]]
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[[Category: Ruyken, M.]]
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[[Category: Scheepmaker, L.]]
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[[Category: Stapels, D A.C.]]
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[[Category: Azurophilic granule]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Innate immunity]]
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[[Category: Primarily beta]]
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[[Category: Protease inhibitor]]
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[[Category: Serine protease]]

Revision as of 16:31, 20 August 2014

Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases

4nzl, resolution 1.85Å

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