1drs
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1drs.gif|left|200px]] | + | [[Image:1drs.gif|left|200px]] |
| - | + | ||
| - | '''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN''' | + | {{Structure |
| + | |PDB= 1drs |SIZE=350|CAPTION= <scene name='initialview01'>1drs</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1DRS is a [ | + | 1DRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin., Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA, Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:[http:// | + | Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin., Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA, Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7634091 7634091] |
[[Category: Dendroaspis jamesoni kaimosae]] | [[Category: Dendroaspis jamesoni kaimosae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 20: | Line 29: | ||
[[Category: cell adhesion protein]] | [[Category: cell adhesion protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:43:20 2008'' |
Revision as of 08:43, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN
Overview
Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.
About this Structure
1DRS is a Single protein structure of sequence from Dendroaspis jamesoni kaimosae. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin., Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA, Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:7634091
Page seeded by OCA on Thu Mar 20 10:43:20 2008
