Carnitine palmitoyltransferase
From Proteopedia
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| - | '''Carnitine palmitoyltransferase''' (CPT I and CPT II) are involved in the transport of long-chain fatty acids into the mitochondria where they are oxidized. Fatty acids form a conjugate with CoA before being oxidized in the mitochondria. However, the CoA-long-chain fatty acid conjugates can not diffuse into the mitochondria. CPT I is a membrane protein which substitutes the CoA in the long-chain fatty acids by carnitine. After entering the mitochondria, CPT II exchanges the carnitine by CoA, enabling the oxidation of the long-chain fatty acids. CPT I is important in fatty acid disorders like diabetes. | + | '''Carnitine palmitoyltransferase''' (CPT I and CPT II) are involved in the transport of long-chain fatty acids into the mitochondria where they are oxidized. Fatty acids form a conjugate with CoA before being oxidized in the mitochondria. However, the CoA-long-chain fatty acid conjugates can not diffuse into the mitochondria. '''CPT I''' is a membrane protein which substitutes the CoA in the long-chain fatty acids by carnitine. After entering the mitochondria, '''CPT II''' exchanges the carnitine by CoA, enabling the oxidation of the long-chain fatty acids. CPT I is important in fatty acid disorders like diabetes. |
==3D structures of carnitine palmitoyltransferase== | ==3D structures of carnitine palmitoyltransferase== | ||
Revision as of 10:36, 25 August 2014
Carnitine palmitoyltransferase (CPT I and CPT II) are involved in the transport of long-chain fatty acids into the mitochondria where they are oxidized. Fatty acids form a conjugate with CoA before being oxidized in the mitochondria. However, the CoA-long-chain fatty acid conjugates can not diffuse into the mitochondria. CPT I is a membrane protein which substitutes the CoA in the long-chain fatty acids by carnitine. After entering the mitochondria, CPT II exchanges the carnitine by CoA, enabling the oxidation of the long-chain fatty acids. CPT I is important in fatty acid disorders like diabetes.
3D structures of carnitine palmitoyltransferase
Updated on 25-August-2014
2h4t, 2fyo, 2deb – rCPT II – rat
2fw3 - rCPT II + antidiabetic drug
2rcu – rCPT II + substrate analog
4ep9, 4eph, 4eyw - rCPT II + inhibitor
2le3 – hCPT I regulatory domain – human - NMR
2m76 - hCPT I regulatory domain – NMR
