Chitinase
From Proteopedia
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{{STRUCTURE_1edq| PDB=1edq | SIZE=400| SCENE=Chitinases/Cv/2 |right|CAPTION=Chitinase I from ''Serratia marcescens'', [[1edq]] }} | {{STRUCTURE_1edq| PDB=1edq | SIZE=400| SCENE=Chitinases/Cv/2 |right|CAPTION=Chitinase I from ''Serratia marcescens'', [[1edq]] }} | ||
| - | + | [[Chitinase]]s cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. | |
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| - | [[Chitinase]]s cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. | + | |
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== 3D Structures of Chitinase == | == 3D Structures of Chitinase == | ||
Revision as of 07:27, 26 August 2014
Chitinases cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium (1ctn) and a plant (2hvm). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed.
Contents |
3D Structures of Chitinase
Updated on 26-August-2014
Chitinase I
3aro, 3b8s – VhChi residues 22-597 – Vibrio harveyi
3b9e - VhChi residues 22-597 (mutant)
1k85 – BcChi fibronectin domain – Bacillus circulans – NMR
1itx - BcChi catalytic domain
1ed7 – BcChi chitin-binding domain - NMR
1ll6, 1ll7 - CiChi residues 36-427 (mutant) – Coccicioides immitis
1d2k - CiChi residues 36-427
3n11 – BcChi – Bacillus cereus
3iwr, 2dkv – Chi residues 33-340 – Japanese rice
1edq, 1ctn, 4axn - SmChi – Serratia marcescens
1x6l, 1rd6 – SmChi (mutant)
3g6l - BoChi residues 21-426 – Bionectria ochroleuca
3oa5, 4dws – Chi – Yersinia entomophaga
3w4r – Chi – corn borer
Chitinase I binary complex
3arp, 3arq, 3arr, 3ars, 3art, 3aru, 3arv, 3arw, 3arx, 3ary, 3arz – VhChi residues 22-597 + inhibitor
3as0, 3as1, 3as2, 3as3 – VhChi residues 22-597 (mutant) + inhibitor
3b9a, 3b9d - VhChi residues 22-597 + polysaccharide
2xvn, 2xuc – AfChi residues 29-307 + inhibitor – Aspergillus fumigatus
3n13, 3n15, 3n17, 3n18 – BcChi (mutant) + NAG
3n12 – BcChi + Zn
3n1a - BcChi (mutant) + inhibitor
1x6n - SmChi (mutant) + inhibitor
1ffq - SmChi + inhibitor
1nh6, 1k9t, 1ffr, 1eib, 1ehn - SmChi (mutant) + polysaccharide
2wk2, 2wly, 2wlz, 2wm0 – SmChi residues 2-520 + inhibitor
3g6m - BoChi residues 21-426 + caffeine
1waw, 1wb0 – hChi catalytic domain polypeptide – human
1hkk, 1hkm, 3rm4, 3rm8, 3rm9, 3rme – hChi catalytic domain inhibitor
1ll4 - CiChi residues 36-427 + inhibitor
Chitinase II
1e15, 3wd0 - SmChi
1ogb, 1goi, 1e6p - SmChi (mutant)
1kfw – Chi catalytic domain – Arthrobacter
1dxj – Chi – Jack bean
Chitinase II binary complex
1ogg, 1ur9 - SmChi (mutant) + inhibitor
1e6n - SmChi (mutant) + polysaccharide
1ur8, 1gpf, 1e6r, 3wd1, 3wd2, 3wd3, 3wd4 - SmChi + inhibitor
1e6z – SmChi + intermediate
2a3a, 2a3b, 2a3c, 2a3e – AfChi + inhibitor
1w1p, 1w1t, 1w1v, 1w1y, 1o6i, 1h0g, 1h0i – SmChi + polypeptide
Chitinase III
2dbt, 1wvu – SgChi residues 30-294 – Streptomyces griseus
1wvv - SgChi residues 30-294 (mutant)
2d49 – SgChi chitin-binding domain - NMR
2xvp – AfChi
2xtk – AfChi + inhibitor
Chitinase IV
3hbd, 3hbe, 3hbh - Chi catalytic domain – Norway spruce
Chitinase V
3alf – tChi residues 26-377 – tobacco
Chitinase V binary complex
3alg - tChi residues 26-377 (mutant) + NAG
3chc, 3chd, 3che, 3chf - AfChi + polypeptide
3ch9, 2iuz – AfChi + inhibitor
Chitinase VIII
2cjl - Chi residues 41-244 – Streptomyces coelicolor
Chitinase XVIII
3sim – Chi – Crocus vernus
Chitinase C
4dyg – RyChiC + NAG – Rye
4dwx - RyChiC
4j0l – RyChiC + GlcNAC
Chitinase
1wno, 1w9p - AfChi
2dsk - PfChi catalytic domain – Pyrococcus furiosus
3afb - PfChi catalytic domain (mutant)
1cns – Chi – Hordeum vulgare
2czn - PfChi chitin-binding domain – NMR
2cwr - PfChi chitin-binding domain
3ian – Chi (mutant) – Lactococcus lactis
3fxy - hChi catalytic domain
1lq0 - hChi residues 22-286
1guv - hChi residues 22-387
3fnd, 3co4 – Chi – Bacteroides thetaiotamicron
3cql – Chi – Carica papaya
2z37 - BjChi catalytic domain – Brassica juncea
2z39 – BjChi catalytic domain (mutant)
2uy2 – yChi residues 22-315 – yeast
4hmc – MmChi 60 – Moritella marina
3w3e – Chi – cowpea
3w6b – RaChi catalytic domain – Ralstonia
3w6e – RaChi catalytic domain (mutant)
Chitinase binary complex
3a4w, 3a4x – PfChi catalytic domain (mutant) + NAG
1lg1 - hChi residues 22-387 + chitobiose
1lg2 - hChi residues 22-387 + ethylene glycol
3fy1, 2ybt, 2ybu - hChi catalytic domain + inhibitor
1hki, 1hkj - hChi + inhibitor
2z38 - BjChi catalytic domain + Cl
2uy3, 2uy4, 2uy5 - yChi residues 22-315 + inhibitor
1w9v, 1w9u - AfChi + polypeptide
4hmd – MmChi 60 + intermediate
4hme – MmChi 60 + NAG
3w6c – RaChi catalytic domain + disaccharide
3w6d, 3w6f – RaChi catalytic domain (mutant) + polysaccharide
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Marcin Jozef Suskiewicz, Anastassis Perrakis
