Neuropilin
From Proteopedia
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{{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ion, [[2qqm]] }} | {{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ion, [[2qqm]] }} | ||
| - | '''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A | + | '''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2.<br /> |
| + | * '''NRP-1''' has high affinity for semaphorin-3A.<br /> | ||
| + | * '''NRP-2''' has high affinity for semaphorin-3F. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
Revision as of 07:56, 2 September 2014
Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2.
- NRP-1 has high affinity for semaphorin-3A.
- NRP-2 has high affinity for semaphorin-3F.
3D Structures of Neuropilin
Updated on 02-September-2014
NRP-1
1kex, 2qqi – hNRP-1 B domain – human
2qqm - hNRP-1 A+B domain
4deq - hNRP-1 B domain + VEGF-A heparin-binding domain
2qqn - hNRP-1 B domain + VEGF-blocking antibody
3i97 - hNRP-1 B domains + inhibitor
2orx – rNRP-1 C1+C2 domains – rat
2orz – rNRP-1 + tuftsin peptide
4gz9 - mNRP-1 A+B domain – mouse
4gza - mNRP-1 A+B domain + plexin A2 + semaphorin 3A
NRP-2
2qqj - hNRP-2 B domain
2qqo - hNRP-2 A+B domains
2qqk, 2qql - hNRP-2 A+B domains + semaphorin-blocking antibody
