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2kka

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[[Image:2kka.png|left|200px]]
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==Human telomere DNA two-tetrad quadruplex structure in K+ solution==
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<StructureSection load='2kka' size='340' side='right' caption='[[2kka]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kka]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI:2-DEOXYINOSINE-5-MONOPHOSPHATE'>DI</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hy9|2hy9]], [[2jpz|2jpz]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kka OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kka RCSB], [http://www.ebi.ac.uk/pdbsum/2kka PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
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{{STRUCTURE_2kka| PDB=2kka | SCENE= }}
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Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures.,Zhang Z, Dai J, Veliath E, Jones RA, Yang D Nucleic Acids Res. 2010 Jan;38(3):1009-21. Epub 2009 Nov 27. PMID:19946019<ref>PMID:19946019</ref>
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===Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19946019}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kka]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKA OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019946019</ref><references group="xtra"/>
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[[Category: Dai, J.]]
[[Category: Dai, J.]]
[[Category: Yang, D.]]
[[Category: Yang, D.]]

Revision as of 05:57, 24 September 2014

Human telomere DNA two-tetrad quadruplex structure in K+ solution

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