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| - | ==Human CD81 Large extracellular loop==
| + | REMOVED: The PDB entry 4bkh was removed. |
| - | <StructureSection load='4bkh' size='340' side='right' caption='[[4bkh]], [[Resolution|resolution]] 1.40Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4bkh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKH OCA]. <br>
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| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene><br>
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| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g8q|1g8q]]</td></tr>
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| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkh RCSB], [http://www.ebi.ac.uk/pdbsum/4bkh PDBsum]</span></td></tr>
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| - | <table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Abrescia, N G.]]
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| - | [[Category: Cunha, E S.]]
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| - | [[Category: Ondiviela, M.]]
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| - | [[Category: Roversi, P.]]
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| - | [[Category: Wojtas, M N.]]
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| - | [[Category: Hcv]]
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| - | [[Category: Immune system]]
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| - | [[Category: Receptor]]
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| - | [[Category: Tetraspanin]]
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