1em2

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[[Image:1em2.jpg|left|200px]]<br /><applet load="1em2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1em2.jpg|left|200px]]
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caption="1em2, resolution 2.2&Aring;" />
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'''STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64'''<br />
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{{Structure
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|PDB= 1em2 |SIZE=350|CAPTION= <scene name='initialview01'>1em2</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=TAR:D(-)-TARTARIC ACID'>TAR</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1EM2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=TAR:'>TAR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM2 OCA].
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1EM2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM2 OCA].
==Reference==
==Reference==
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Structure and lipid transport mechanism of a StAR-related domain., Tsujishita Y, Hurley JH, Nat Struct Biol. 2000 May;7(5):408-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10802740 10802740]
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Structure and lipid transport mechanism of a StAR-related domain., Tsujishita Y, Hurley JH, Nat Struct Biol. 2000 May;7(5):408-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10802740 10802740]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: beta barrel]]
[[Category: beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:29:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:57:25 2008''

Revision as of 08:57, 20 March 2008

Image:1em2.jpg


PDB ID 1em2

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64


Overview

The steroidogenic acute regulatory protein (StAR) regulates acute steroidogenesis in the adrenal cortex and gonads by promoting the translocation of cholesterol to the mitochondrial inner membrane where the first step in steriod biosynthesis is catalyzed. StAR-related lipid transfer (START) domains occur in proteins involved in lipid transport and metabolism, signal transduction, and transcriptional regulation. The 2.2 A resolution crystal structure of the START domain of human MLN64 reported here reveals an alpha/beta fold built around a U-shaped incomplete beta-barrel. The interior of the protein encompasses a 26 x 12 x 11 A hydrophobic tunnel that is large enough to bind a single cholesterol molecule. The StAR and MLN64 START domains bind 1 mole of 14C cholesterol per mole of protein in vitro. Based on the START domain structure and cholesterol binding stoichiometry, it is proposed that StAR acts by shuttling cholesterol molecules one at a time through the intermembrane space of the mitochondrion.

About this Structure

1EM2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and lipid transport mechanism of a StAR-related domain., Tsujishita Y, Hurley JH, Nat Struct Biol. 2000 May;7(5):408-14. PMID:10802740

Page seeded by OCA on Thu Mar 20 10:57:25 2008

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