1eqd

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[[Image:1eqd.gif|left|200px]]<br /><applet load="1eqd" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1eqd.gif|left|200px]]
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caption="1eqd, resolution 1.6&Aring;" />
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'''CRYSTAL STRUCTURE OF NITROPHORIN 4 COMPLEXED WITH CN'''<br />
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{{Structure
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|PDB= 1eqd |SIZE=350|CAPTION= <scene name='initialview01'>1eqd</scene>, resolution 1.6&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEV:5,8-DIMETHYL-1,2,3,4-TETRAVINYLPORPHINE-6,7-DIPROPIONIC+ACID+FERROUS+COMPLEX'>HEV</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF NITROPHORIN 4 COMPLEXED WITH CN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1EQD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus] with <scene name='pdbligand=CYN:'>CYN</scene>, <scene name='pdbligand=HEV:'>HEV</scene> and <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQD OCA].
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1EQD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQD OCA].
==Reference==
==Reference==
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Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial., Weichsel A, Andersen JF, Roberts SA, Montfort WR, Nat Struct Biol. 2000 Jul;7(7):551-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10876239 10876239]
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Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial., Weichsel A, Andersen JF, Roberts SA, Montfort WR, Nat Struct Biol. 2000 Jul;7(7):551-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10876239 10876239]
[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: lipocalin fold]]
[[Category: lipocalin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:59:01 2008''

Revision as of 08:59, 20 March 2008

Image:1eqd.gif


PDB ID 1eqd

Drag the structure with the mouse to rotate
, resolution 1.6Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF NITROPHORIN 4 COMPLEXED WITH CN


Overview

The nitrophorins comprise an unusual family of proteins that use ferric (Fe(III)) heme to transport highly reactive nitric oxide (NO) from the salivary gland of a blood sucking bug to the victim, resulting in vasodilation and reduced blood coagulation. We have determined structures of nitrophorin 4 in complexes with H2O, cyanide and nitric oxide. These structures reveal a remarkable feature: the nitrophorins have a broadly open distal pocket in the absence of NO, but upon NO binding, three or more water molecules are expelled and two loops fold into the distal pocket, resulting in the packing of hydrophobic groups around the NO molecule and increased distortion of the heme. In this way, the protein apparently forms a 'hydrophobic trap' for the NO molecule. The structures are very accurate, ranging between 1.6 and 1.4 A resolutions.

About this Structure

1EQD is a Single protein structure of sequence from Rhodnius prolixus. Full crystallographic information is available from OCA.

Reference

Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial., Weichsel A, Andersen JF, Roberts SA, Montfort WR, Nat Struct Biol. 2000 Jul;7(7):551-4. PMID:10876239

Page seeded by OCA on Thu Mar 20 10:59:01 2008

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