This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1k09

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1k09" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1k09.png|left|200px]]
+
==Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein==
 +
<StructureSection load='1k09' size='340' side='right' caption='[[1k09]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1k09]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K09 FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=CLG:2-AMINO-6-[2-(2-AMINOOXY-ACETYLAMINO)-ACETYLAMINO]-HEXANOIC+ACID'>CLG</scene>, <scene name='pdbligand=CLH:2-AMINO-6-[2-(2-OXO-ACETYLAMINO)-ACETYLAMINO]-HEXANOIC+ACID'>CLH</scene>, <scene name='pdbligand=MPT:BETA-MERCAPTOPROPIONIC+ACID'>MPT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k09 RCSB], [http://www.ebi.ac.uk/pdbsum/1k09 PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.
-
{{STRUCTURE_1k09| PDB=1k09 | SCENE= }}
+
BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein.,Carulla N, Woodward C, Barany G Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452<ref>PMID:12021452</ref>
-
===Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_12021452}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1k09]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA].
+
</StructureSection>
[[Category: Barany, G.]]
[[Category: Barany, G.]]
[[Category: Carulla, N.]]
[[Category: Carulla, N.]]

Revision as of 10:23, 28 September 2014

Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k09"
Views
Personal tools
Navigation
Toolbox