1jhi

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[[Image:1jhi.png|left|200px]]
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==Solution Structure of a Hedamycin-DNA complex==
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<StructureSection load='1jhi' size='340' side='right' caption='[[1jhi]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jhi]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEH:HEDAMYCIN'>HEH</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jhi RCSB], [http://www.ebi.ac.uk/pdbsum/1jhi PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hedamycin, a member of the pluramycin family of drugs, displays a range of biological responses including antitumor and antimicrobial activity. The mechanism of action is via direct interaction with DNA through intercalation between the bases of the oligonucleotide and alkylation of a guanine residue at 5'-PyG-3' sites. There appears to be some minor structural differences between two earlier studies on the interaction of hedamycin with 5'-PyG-3' sites. In this study, a high-resolution NMR analysis of the hedamycin:d(ACCGGT)2 complex was undertaken in order to investigate the effect of replacing the thymine with a guanine at the preferred 5'-CGT-3' site. The resultant structure was compared with earlier work, with particular emphasis placed on the drug conformation. The structure of the hedamycin:d(ACCGGT)2 complex has many features in common with the two previous NMR structures of hedamycin:DNA complexes but differed in the conformation and orientation of the N,N-dimethylvancosamine saccharide of hedamycin in one of these structures. The preferential binding of hedamycin to 5'-CG-3' over 5'-TG-3' binding sites is explained in terms of the orientation and location of the N,N-dimethylvancosamine saccharide in the minor groove.
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{{STRUCTURE_1jhi| PDB=1jhi | SCENE= }}
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Structural investigation of the hedamycin:d(ACCGGT)2 complex by NMR and restrained molecular dynamics.,Owen EA, Burley GA, Carver JA, Wickham G, Keniry MA Biochem Biophys Res Commun. 2002 Feb 8;290(5):1602-8. PMID:11820806<ref>PMID:11820806</ref>
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===Solution Structure of a Hedamycin-DNA complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11820806}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1jhi]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHI OCA].
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</StructureSection>
[[Category: Burley, G A.]]
[[Category: Burley, G A.]]
[[Category: Carver, J A.]]
[[Category: Carver, J A.]]

Revision as of 11:00, 28 September 2014

Solution Structure of a Hedamycin-DNA complex

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