1exf
From Proteopedia
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| - | [[Image:1exf.jpg|left|200px]] | + | [[Image:1exf.jpg|left|200px]] |
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| - | '''EXFOLIATIVE TOXIN A''' | + | {{Structure |
| + | |PDB= 1exf |SIZE=350|CAPTION= <scene name='initialview01'>1exf</scene>, resolution 2.1Å | ||
| + | |SITE= <scene name='pdbsite=CAT:Catalytic+Site'>CAT</scene> | ||
| + | |LIGAND= <scene name='pdbligand=GLY:GLYCINE'>GLY</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''EXFOLIATIVE TOXIN A''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1EXF is a [ | + | 1EXF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXF OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease., Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH, Biochemistry. 1997 Feb 18;36(7):1559-66. PMID:[http:// | + | The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease., Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH, Biochemistry. 1997 Feb 18;36(7):1559-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9048539 9048539] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
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[[Category: superantigen]] | [[Category: superantigen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:01:31 2008'' |
Revision as of 09:01, 20 March 2008
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| , resolution 2.1Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
EXFOLIATIVE TOXIN A
Overview
Exfoliative toxin A (ETA) causes staphylococcal scalded skin syndrome which is characterized by a specific intraepidermal separation of layers of the skin. The mechanism by which ETA causes skin separation is unknown although protease or superantigen activity has been implicated. The X-ray crystal structure of ETA has been solved in two crystal forms to 2.1 and 2.3 A resolution and R-factors of 17% and 19%, respectively. The structures indicate that ETA belongs to the chymotrypsin-like family of serine proteases and cleaves substrates after acidic residues. The conformation of a loop adjacent to the catalytic site is suggested to be key in regulating the proteolytic activity of ETA through controlling whether the main chain carbonyl group of Pro192 occupies the oxyanion hole. A unique amino-terminal domain containing a 15-residue amphipathic alpha helix may also be involved in protease activation through binding a specific receptor. Substitution of the active site serine residue with cysteine abolishes the ability of ETA to produce the characteristic separation of epidermal layers but not its ability to induce T cell proliferation.
About this Structure
1EXF is a Single protein structure of sequence from Staphylococcus aureus and Unidentified. Full crystallographic information is available from OCA.
Reference
The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease., Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH, Biochemistry. 1997 Feb 18;36(7):1559-66. PMID:9048539
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